Chunyuan Hou, Nan Han, Bin Zhu, Xinming Li, Junmin Xi, Jianguo Fang*, Yu Zhang* and Jun Luo*,
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Editing Benzotrithiophene-Based Covalent Organic Frameworks for Developing New Sonosensitizers
Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF and BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor–acceptor (D–A) structures optimize the band position of the COFs and endow them with good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent sonodynamic therapeutic effect. Particularly, because of the enhanced D–A effect that promotes charge separation and transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight the great potential of elaborate editing COFs with D–A configurations as suitable candidates for advanced sonosensitizers.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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