近红外纳米体温计揭示器官与体表温度差异,预防中暑

IF 9.1 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Meilin Liu, Yaru Sun, Yi Zhang*, Yufu Liu, Zhengbing Liang, Junhao Liu, Hongbao Xin, Xiancheng Zeng* and Qingsong Mei*, 
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引用次数: 0

摘要

中暑时,器官温度往往与体表温度有显著差异,导致急性器官衰竭,尽管体温是持续控制的。然而,由于缺乏实时监测器官温度波动的无创技术,它们之间的确切温度差异仍不清楚。在此,我们开发了一种近红外发射纳米温度计,通过共掺杂Nd3+和Yb3+,在808 nm激发下产生980和1330 nm两个不同的发射。这些辐射表现出对温度变化的不同响应,从而能够构建用于精确温度检测的比例纳米探针。值得注意的是,经静脉注射后,纳米探针在小鼠肝脏中迅速积累,表明肝脏的温度始终比直肠高约1.5℃。此外,发现肝损伤开始于42°C的直肠温度,而不是传统中暑模型中使用的43°C。这些发现介绍了一个强大的纳米温度计,以准确地了解热相关疾病的病理进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Near-Infrared Nanothermometer Reveals Temperature Discrepancy between Organs and Body Surface for Heatstroke Prevention

Near-Infrared Nanothermometer Reveals Temperature Discrepancy between Organs and Body Surface for Heatstroke Prevention

Organ temperatures often vary significantly from body surface temperatures during heatstroke, leading to acute organ failure, although body temperature is continuously controlled. However, the exact temperature discrepancy between them remains unclear due to a lack of noninvasive techniques for real-time monitoring of organ temperature fluctuations. Herein, we developed a near-infrared emissive nanothermometer by codoping Nd3+ and Yb3+ to produce two distinct emissions at 980 and 1330 nm under 808 nm excitation. These emissions demonstrated differential responses to temperature variations, enabling the construction of a ratiometric nanoprobe for accurate temperature detection. Notably, the nanoprobe rapidly accumulated in mouse liver after intravenous injection, revealing that liver showed consistently higher temperature than rectum by approximately 1.5 °C. Moreover, liver injury was found to begin at a rectal temperature of 42 °C, rather than the 43 °C conventionally used in heatstroke models. These findings introduce a robust nanothermometer for accurately understanding the pathological progression of heat-related illnesses.

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来源期刊
Nano Letters
Nano Letters 工程技术-材料科学:综合
CiteScore
16.80
自引率
2.80%
发文量
1182
审稿时长
1.4 months
期刊介绍: Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.
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