固定化CD8+ T细胞抗肿瘤免疫

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-03-11 DOI:10.1016/j.immuni.2025.02.015

Scott A. Read, Golo Ahlenstiel

引用次数: 0

摘要

肝癌对免疫检查点阻断的反应很差。在最近一期《科学》杂志上，Varanasi 等人揭示了胆汁酸如何抑制肝脏中的抗肿瘤 CD8+ T 细胞反应，从而导致癌症进展和免疫治疗效果不佳。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immo-bile-izing CD8+ T cell anti-tumor immunity

Hepatocellular carcinoma is poorly responsive to immune checkpoint blockade. In a recent issue of Science, Varanasi et al. reveal how bile acids dampen anti-tumor CD8⁺ T cell responses in the liver, contributing to cancer progression and poor immunotherapy outcomes.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.