组织常驻NK细胞的分化：为什么起源和环境问题

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-03-11 DOI:10.1016/j.immuni.2025.02.020

Christin Friedrich, Tommaso Torcellan, Georg Gasteiger

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引用次数: 0

摘要

在致免疫的信中，deglii - esposti及其同事讨论了组织常驻自然杀伤细胞（trNK）的潜在起源以及使其分化的炎症环境。这些基本上尚未解决的问题与基于nk的细胞疗法和我们对组织免疫的理解有关。在这里，我们研究了他们的工作与我们最近的工作之间的主要互补性和差异，2突出了未来的挑战和开放的研究问题。TrNK细胞是在利益声明中发现的，作者声明没有利益竞争。

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Differentiation of tissue-resident NK cells: Why origin and context matter

Section snippets

Main text

In their letter to Immunity, Degli-Esposti and colleagues¹ discuss the potential origins of tissue-resident natural killer (trNK) cells and the inflammatory contexts enabling their differentiation. These largely unresolved issues are relevant for NK-based cellular therapies and our understanding of tissue immunity. Here, we examine key complementarities and differences between their work and our recent work,² highlighting future challenges and open research questions.TrNK cells are found in a

Declaration of interests

The authors declare no competing interests.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.