NK常驻记忆细胞是由NK细胞在组织中积累而产生的，不受持续局部感染的影响

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-03-11 DOI:10.1016/j.immuni.2025.02.019

Iona S. Schuster, Matthew E. Wikstrom, Christopher E. Andoniou, Mariapia A. Degli-Esposti

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引用次数: 0

摘要

Gasteiger及其同事最近的一项研究描述了在局部病毒（牛痘病毒）和细菌（金黄色葡萄球菌）感染后，循环的自然杀伤（NK）细胞群被招募并保留在皮肤中数周。这些细胞，作者称之为组织常驻（tr）NK细胞，在再次攻击时表现出效应分子（干扰素[IFN]-γ，颗粒酶B [Gzmb]，穿孔素[Prf1]）的增加，表明在增强病原体中起作用。这项工作得到了澳大利亚国家卫生和医学研究委员会（NHMRC 2004397, 1119298，和2026377）的资助。利益声明作者声明无利益冲突。

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NK resident memory cells arise from NK cells that accumulate in tissues independently of persistent local infection

Section snippets

Main text

A recent study by Gasteiger and colleagues¹ described a population of circulating natural killer (NK) cells that are recruited and retained in the skin for several weeks following local viral (vaccinia virus) and bacterial (Staphylococcus aureus) infections. These cells, which the authors refer to as tissue resident (tr)NK cells, exhibit increased production of effector molecules (interferon [IFN]-γ, granzyme B [Gzmb], perforin [Prf1]) upon re-challenge, suggesting a role in enhanced pathogen

Acknowledgments

The work was supported by funding from the National Health and Medical Research Council of Australia (NHMRC 2004397, 1119298, and 2026377).

Declaration of interests

The authors declare no competing interests.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.