通过可逆比率荧光策略阐明Wilson病中铜中毒相关的氧化还原动力学

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-03-12 DOI:10.1039/d4cc06677d

Shunping Zang , Qingguo He , Yuyang Zeng , Yuyang Huang , Benhua Wang , Qing Liu , Xiangzhi Song

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引用次数: 0

摘要

使用可逆比例HOCl/GSH荧光探针WD- redox揭示了铜增生和威尔逊病（WD）的氧化还原动力学。它可以显示过量铜积累引起的氧化还原失衡，并监测d -青霉胺的治疗效果。该探针在研究铜代谢紊乱的氧化应激和评价药物疗效方面的效用已得到证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy†

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Elucidating cuproptosis-linked redox dynamics in Wilson's disease via a reversible ratiometric fluorescence strategy†

The redox dynamics in cuproptosis and Wilson's disease (WD) were revealed using a reversible and ratiometric fluorescent probe, . It visualizes redox imbalances caused by excessive copper accumulation and monitors therapeutic effects of d-penicillamine. The probe's utility in studying oxidative stress in copper metabolism disorders and evaluating drug efficacy has been demonstrated.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.