中枢神经系统清除的一个奇怪概念

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-03-11 DOI:10.1038/s41593-025-01897-3

Virginia Plá, Erik Kroesbergen, Saiyue Deng, Michael J. Giannetto, Lauren M. Hablitz, Evan Newbold, Antonio Ladrón-de-Guevara, Tina Esmail, Ryszard Stefan Gomolka, Yuki Mori, Steven A. Goldman, Douglas H. Kelley, John H. Thomas, Maiken Nedergaard

引用次数: 0

摘要

源于 A. Miao 等人的研究。Nature Neuroscience https://doi.org/10.1038/s41593-024-01638-y (2024)在过去十年中，多项研究表明，与清醒状态相比，睡眠会减少淀粉样蛋白-β和tau的负担，而且在人脑和小鼠大脑中，睡眠期间的glymphatic清除率会增加1,2,3,4,5,6。Miao等人最近的一项研究7 对这些发现提出了质疑。我们在此对 Miao 等人 7 的研究中的实验方法、分析的严谨性以及理论和数学假设提出质疑。该研究的结论--睡眠和麻醉期间脑清除率降低--并没有得到相关数据的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A curious concept of CNS clearance

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A curious concept of CNS clearance

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.