{"title":"Effect of Passive Immunotherapeutics (IgY) on S. Mutans in Caries Active Children 8-11 Years of Age.","authors":"Antarmayee Panigrahi, Snigdha Pattanaik, Noorjahan Mohammad, Subhrajeet N Sahoo, Swati Patnaik, Debarchita Sarangi","doi":"10.4103/jpbs.jpbs_904_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Dental caries is a multifactorial disease caused by combined effect of host, environment, and microorganism. Mutans Streptococci (MS) is the main microorganism in causing and progression of dental caries. Advances in science and technology led to attempt in managing dental caries by targeting its initiation and delaying its progress. Immunoglobulin Y has proven efficacy in reducing the colonisation of S. Mutans by affecting the adhesion.</p><p><strong>Aim: </strong>Thus the present study was undertaken to evaluate the effect of passive immunisation on S.Mutans levels in caries active children aged 8-11 yrs of age.</p><p><strong>Materials and methods: </strong>Total of 50 children were randomly divided into IgY mouthspray (Test Group) and 0.9% Saline (Control group). Saliva sample were collected and subjected to microbial examination using MSB agar at the end of 30 days of study period.</p><p><strong>Results: </strong>Within the limitations, it can be concluded that IgY mouthspray significantly reduces the adhesion and growth of the causative agent S.Mutans in caries active children.</p><p><strong>Conclusion: </strong>Use of passive immunisation significantly reduces the bacterial overload and thus decreasing the dental caries in high risk children.</p>","PeriodicalId":94339,"journal":{"name":"Journal of pharmacy & bioallied sciences","volume":"16 Suppl 5","pages":"S4448-S4451"},"PeriodicalIF":0.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11888708/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacy & bioallied sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jpbs.jpbs_904_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/30 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Effect of Passive Immunotherapeutics (IgY) on S. Mutans in Caries Active Children 8-11 Years of Age.
Introduction: Dental caries is a multifactorial disease caused by combined effect of host, environment, and microorganism. Mutans Streptococci (MS) is the main microorganism in causing and progression of dental caries. Advances in science and technology led to attempt in managing dental caries by targeting its initiation and delaying its progress. Immunoglobulin Y has proven efficacy in reducing the colonisation of S. Mutans by affecting the adhesion.
Aim: Thus the present study was undertaken to evaluate the effect of passive immunisation on S.Mutans levels in caries active children aged 8-11 yrs of age.
Materials and methods: Total of 50 children were randomly divided into IgY mouthspray (Test Group) and 0.9% Saline (Control group). Saliva sample were collected and subjected to microbial examination using MSB agar at the end of 30 days of study period.
Results: Within the limitations, it can be concluded that IgY mouthspray significantly reduces the adhesion and growth of the causative agent S.Mutans in caries active children.
Conclusion: Use of passive immunisation significantly reduces the bacterial overload and thus decreasing the dental caries in high risk children.
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