胶质母细胞瘤三十年的光动力疗法：综合科学计量学分析。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-03-05 DOI:10.1016/j.pdpdt.2025.104533

Jiheng Zhang , Xiuwei Yan , Xin Gao , Jiahe Hu , Hongtao Zhao , Chengyun Yang , Lei Xu , Yapeng Niu , Mo Geng , Nan Wang , Shaoshan Hu

{"title":"胶质母细胞瘤三十年的光动力疗法：综合科学计量学分析。","authors":"Jiheng Zhang , Xiuwei Yan , Xin Gao , Jiahe Hu , Hongtao Zhao , Chengyun Yang , Lei Xu , Yapeng Niu , Mo Geng , Nan Wang , Shaoshan Hu","doi":"10.1016/j.pdpdt.2025.104533","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) has emerged as a promising adjunctive treatment for glioblastoma (GBM), yet a comprehensive bibliometric analysis of this field is lacking. This study explores research trends, major contributors, and hotspots in PDT for GBM to provide an integrated overview of its development.</div></div><div><h3>Methods</h3><div>Literature from 1993 to 2024 was retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace, analyzed publication trends, collaborations, and keyword co-occurrence to identify influential authors, institutions, and journals.</div></div><div><h3>Results</h3><div>A total of 799 publications showed a growing research interest, peaking in 2022. The United States and China were leading contributors, with prominent institutions like the University of California System and Centre National de la Recherche Scientifique. Influential figures, such as Jiro Akimoto and Walter Stummer, advanced clinical applications and fluorescence-guided techniques. Early studies of PDT for GBM have focused on evaluating its efficacy and potential side effects, while recent research has transitioned toward innovative strategies like targeted drug delivery, nanotechnology, and combination therapies. However, the similarities between early and recent studies are in the search for safe and reliable photosensitizers. Keyword analysis highlighted \"5-aminolevulinic acid\", \"in vitro\", and \"polyethylene glycol compounds\" as key areas, while timeline analysis revealed shifts from foundational photosensitizer research to approaches addressing tumor heterogeneity and resistance.</div></div><div><h3>Conclusions</h3><div>This study provides a systematic overview of PDT research for GBM, spotlighting breakthroughs and collaborative networks. The findings emphasize the importance of innovation and clinical translation to fully realize PDT's potential in GBM therapy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104533"},"PeriodicalIF":3.1000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric Analysis\",\"authors\":\"Jiheng Zhang , Xiuwei Yan , Xin Gao , Jiahe Hu , Hongtao Zhao , Chengyun Yang , Lei Xu , Yapeng Niu , Mo Geng , Nan Wang , Shaoshan Hu\",\"doi\":\"10.1016/j.pdpdt.2025.104533\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Photodynamic therapy (PDT) has emerged as a promising adjunctive treatment for glioblastoma (GBM), yet a comprehensive bibliometric analysis of this field is lacking. This study explores research trends, major contributors, and hotspots in PDT for GBM to provide an integrated overview of its development.</div></div><div><h3>Methods</h3><div>Literature from 1993 to 2024 was retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace, analyzed publication trends, collaborations, and keyword co-occurrence to identify influential authors, institutions, and journals.</div></div><div><h3>Results</h3><div>A total of 799 publications showed a growing research interest, peaking in 2022. The United States and China were leading contributors, with prominent institutions like the University of California System and Centre National de la Recherche Scientifique. Influential figures, such as Jiro Akimoto and Walter Stummer, advanced clinical applications and fluorescence-guided techniques. Early studies of PDT for GBM have focused on evaluating its efficacy and potential side effects, while recent research has transitioned toward innovative strategies like targeted drug delivery, nanotechnology, and combination therapies. However, the similarities between early and recent studies are in the search for safe and reliable photosensitizers. Keyword analysis highlighted \\\"5-aminolevulinic acid\\\", \\\"in vitro\\\", and \\\"polyethylene glycol compounds\\\" as key areas, while timeline analysis revealed shifts from foundational photosensitizer research to approaches addressing tumor heterogeneity and resistance.</div></div><div><h3>Conclusions</h3><div>This study provides a systematic overview of PDT research for GBM, spotlighting breakthroughs and collaborative networks. The findings emphasize the importance of innovation and clinical translation to fully realize PDT's potential in GBM therapy.</div></div>\",\"PeriodicalId\":20141,\"journal\":{\"name\":\"Photodiagnosis and Photodynamic Therapy\",\"volume\":\"53 \",\"pages\":\"Article 104533\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and Photodynamic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1572100025000638\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025000638","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：光动力疗法（PDT）已成为胶质母细胞瘤（GBM）的一种有前景的辅助治疗方法，但缺乏对该领域的全面文献计量学分析。本研究探讨了GBM PDT的研究趋势、主要贡献者和热点，以提供其发展的综合概述。方法：检索Web of Science Core Collection 1993 - 2024年的文献。包括CiteSpace在内的文献计量工具分析了出版趋势、合作情况和关键词共现情况，以确定有影响力的作者、机构和期刊。结果：共有799篇出版物显示出日益增长的研究兴趣，在2022年达到顶峰。美国和中国是主要贡献者，其中包括加州大学系统和国家科学研究中心等著名机构。有影响力的人物，如次郎秋本和沃尔特斯顿默，先进的临床应用和荧光引导技术。光动力治疗GBM的早期研究主要集中在评估其疗效和潜在副作用，并逐渐转向创新策略，如靶向给药、纳米技术和联合治疗。然而，早期和最近的研究之间的相似之处在于寻找安全可靠的光敏剂。关键词分析强调了“5-氨基乙酰丙酸”、“体外”和“聚乙二醇化合物”是重点领域，而时间轴分析则揭示了从基础光敏剂研究到解决肿瘤异质性和耐药性的方法的转变。结论：本研究对GBM的PDT研究、聚焦突破和协作网络进行了系统概述。研究结果强调了临床前创新和临床转化的重要性，以充分发挥PDT在GBM治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric Analysis

Background

Photodynamic therapy (PDT) has emerged as a promising adjunctive treatment for glioblastoma (GBM), yet a comprehensive bibliometric analysis of this field is lacking. This study explores research trends, major contributors, and hotspots in PDT for GBM to provide an integrated overview of its development.

Methods

Literature from 1993 to 2024 was retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace, analyzed publication trends, collaborations, and keyword co-occurrence to identify influential authors, institutions, and journals.

Results

A total of 799 publications showed a growing research interest, peaking in 2022. The United States and China were leading contributors, with prominent institutions like the University of California System and Centre National de la Recherche Scientifique. Influential figures, such as Jiro Akimoto and Walter Stummer, advanced clinical applications and fluorescence-guided techniques. Early studies of PDT for GBM have focused on evaluating its efficacy and potential side effects, while recent research has transitioned toward innovative strategies like targeted drug delivery, nanotechnology, and combination therapies. However, the similarities between early and recent studies are in the search for safe and reliable photosensitizers. Keyword analysis highlighted "5-aminolevulinic acid", "in vitro", and "polyethylene glycol compounds" as key areas, while timeline analysis revealed shifts from foundational photosensitizer research to approaches addressing tumor heterogeneity and resistance.

Conclusions

This study provides a systematic overview of PDT research for GBM, spotlighting breakthroughs and collaborative networks. The findings emphasize the importance of innovation and clinical translation to fully realize PDT's potential in GBM therapy.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.