Pinar Karacin, Runa Ozelci, Enes Kumcu, Dilek Kaya Kaplanoglu, Serdar Dilbaz, Yaprak Ustun
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引用次数: 0
摘要
目的：评价生长激素（GH）联合治疗体外受精（IVF）控制卵巢刺激的疗效。研究设计：描述性分析。研究地点和时间：2010年1月至2023年，土耳其安卡拉Etlik Zubeyde Hanim培训和研究医院妇科。方法：共有191名接受体外受精周期的卵巢储备功能减退（DOR）妇女被纳入研究。选取研究期间接受GH治疗的89例DOR患者作为研究组（A组），未接受GH治疗的102例DOR患者作为对照组（B组）。采用卡方检验和Mann-Whitney U检验比较各组变量。结果：B组雌二醇、卵泡刺激素基础水平均高于a组，与前核2pn数、收集卵母细胞数无显著相关性。两组临床妊娠率具有可比性[n = 13 (27.7%) vs. n = 19 (35.2%), p = 0.417]。结论：本研究显示GH组临床妊娠率未明显增高。关键词：控制性卵巢过度刺激，生长激素，体外受精，临床妊娠率
Impact of Growth Hormone Co-Treatment in Patients with Diminished Ovarian Reserve on In-Vitro Fertilisation Outcomes.
Objective: To assess the efficacy of growth hormone (GH) co-treatment during controlled ovarian stimulation for in-vitro fertilisation (IVF).
Study design: Descriptive analytical. Place and Duration of the Study: Department of Gynaecology, Etlik Zubeyde Hanim Training and Research Hospital, Ankara, Turkiye, from January 2010 to 2023.
Methodology: A total of 191 women with diminished ovarian reserve (DOR) who underwent IVF cycles were included in the study. Eighty- nine patients with DOR who received GH during the study period were designated as the study group (Group A), and the 102 patients with DOR who did not receive GH were chosen as the control group (Group B). Chi-square and Mann-Whitney U tests were used to compare groups' variables.
Results: The Group B's basal estradiol and FSH levels were higher than those of Group A. No significant correlation was found in regards to number of 2PNs (pro-nuclear), and the count of collected oocytes. The clinical pregnancy rate of the groups was comparable [(n = 13 (27.7%) vs. n = 19 (35.2%), p = 0.417)].
Conclusion: This study has shown that the clinical pregnancy rate did not increase significantly in the GH group.
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