免疫学（你在其他任何地方都不敢读到的科学更新）：X染色体，Xist和女性自身免疫。

IF 0.9 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Revue De Medecine Interne Pub Date : 2025-06-01 DOI:10.1016/j.revmed.2025.02.009

Valentin Lacombe

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引用次数: 0

摘要

这是免疫学系列的第一篇文章，探讨了X染色体和非编码RNA Xist在女性易患自身免疫性疾病中的作用，通过分解三项基础研究，使它们更容易被非专业人士理解。Xist是一种非编码RNA，它通过缠绕在每个女性细胞中的两条X染色体中的一条上而使其失活。在这里，我们将深入探讨Xist如何参与狼疮中抗rnp抗体的产生，TLR7基因如何成为一个叛逆者并逃脱Xist的控制，以及Xist与其X染色体之间缺乏亲和力如何导致其他自身免疫性疾病。让我们认真一点，不把自己太当回事，在自身免疫中揭开Xist的迷人世界！

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immuno’logique (l’actualité scientifique que vous n’auriez pas osé lire ailleurs) : chromosome X, Xist et auto-immunité féminine

This first article in the Immuno’logical series explores the role of the X chromosome and the non-coding RNA Xist in the female predisposition to autoimmune diseases, by breaking down three fundamental research studies to make them more digestible for non-experts. Xist is a non-coding RNA that inactivates one of the two X chromosomes in every female cell by wrapping around it. Here, we dive into how Xist is involved in the production of anti-RNP antibodies in lupus, how the TLR7 gene can be a rebel and escape Xist's control, and how a lack of affinity between Xist and its X chromosome can contribute to other autoimmune diseases. Let's be serious without taking ourselves too seriously, and uncover the fascinating world of Xist in autoimmunity!

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来源期刊

Revue De Medecine Interne 医学-医学：内科

CiteScore

0.70

自引率

11.10%

发文量

526

审稿时长

37 days

期刊介绍： Official journal of the SNFMI, La revue de medecine interne is indexed in the most prestigious databases. It is the most efficient French language journal available for internal medicine specialists who want to expand their knowledge and skills beyond their own discipline. It is also the main French language international medium for French research works. The journal publishes each month editorials, original articles, review articles, short communications, etc. These articles address the fundamental and innumerable facets of internal medicine, spanning all medical specialties. Manuscripts may be submitted in French or in English. La revue de medecine interne also includes additional issues publishing the proceedings of the two annual French meetings of internal medicine (June and December), as well as thematic issues.