Keng-Yu Chang, Tabitha Haun, Zhaoli Liu, Alfredo Gil, Ziba Taherzadeh, Paul J. Fadel, Shane A. Phillips, Mariann R. Piano, Chueh-Lung Hwang
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At-risk drinkers were defined as those who had a dried blood spot phosphatidylethanol level ≥20 ng/mL. All participants completed 24-h ambulatory BP monitoring and urine collection to determine nighttime (or asleep) BP and nighttime urinary catecholamine levels. Sleep quality was determined by using the Pittsburgh Sleep Quality Index.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In midlife adults free of antihypertensive medications, at-risk drinkers had a higher nighttime systolic (118 ± 14 vs. 107 ± 14 mmHg, <i>p</i> = 0.02) and diastolic BP (70 ± 9 vs. 62 ± 9 mmHg, <i>p</i> = 0.003) than low-risk drinkers with no between-group differences in sleep quality component scores (<i>p</i> ≥ 0.14). In midlife adults taking antihypertensive medications, no difference in nighttime BP was found between at-risk drinkers and low-risk drinkers (<i>p</i> ≥ 0.68), with a higher score for the “use of sleeping medication” component in high-risk drinkers (<i>p</i> = 0.02). Regardless of antihypertensive medication use, no difference between at-risk drinkers and low-risk drinkers was found in nighttime urinary catecholamine levels (<i>p</i> ≥ 0.19).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Our findings suggest that in midlife adults free of antihypertensive medication use, at-risk alcohol use is associated with an increase in nighttime BP, and the increase in nighttime BP may be mediated by mechanisms other than increased catecholamines and poor sleep quality.</p>\n </section>\n </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 4","pages":"843-853"},"PeriodicalIF":3.0000,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults\",\"authors\":\"Keng-Yu Chang, Tabitha Haun, Zhaoli Liu, Alfredo Gil, Ziba Taherzadeh, Paul J. 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引用次数: 0
摘要
背景：酒精和高血压之间的关联主要基于办公室血压测量。然而，人们对饮酒对夜间血压的影响及其潜在机制知之甚少。本研究的目的是调查高危饮酒对中年成年人夜间血压、尿儿茶酚胺和睡眠质量的影响。方法：中年男性32例，绝经后女性30例，无重大临床疾病，不吸烟(年龄：58±4；平均值±SD)，均被纳入。在所有参与者中，有22人目前正在服用抗高血压药物。高危饮酒者定义为干血斑磷脂酰乙醇水平≥20 ng/mL的饮酒者。所有参与者都完成了24小时动态血压监测和尿液收集，以确定夜间（或睡眠）血压和夜间尿儿茶酚胺水平。睡眠质量由匹兹堡睡眠质量指数确定。结果：在没有抗高血压药物的中年成年人中，高危饮酒者的夜间收缩压（118±14比107±14 mmHg， p = 0.02）和舒张压（70±9比62±9 mmHg， p = 0.003）高于低危饮酒者，睡眠质量成分评分无组间差异（p≥0.14）。在服用降压药的中年成年人中，高危饮酒者和低危饮酒者夜间血压无差异（p≥0.68），高危饮酒者“使用安眠药”部分得分较高（p = 0.02）。无论是否使用抗高血压药物，夜间尿儿茶酚胺水平在高危饮酒者和低危饮酒者之间没有差异（p≥0.19）。结论：我们的研究结果表明，在没有使用抗高血压药物的中年成年人中，高危饮酒与夜间血压升高有关，夜间血压升高可能是由儿茶酚胺升高和睡眠质量差以外的机制介导的。
Effects of at-risk alcohol use on nighttime blood pressure, urinary catecholamines, and sleep quality in midlife adults
Background
The association between alcohol and hypertension has been predominantly based on office blood pressure (BP) measurements. However, little is known about the effect of alcohol use on nighttime BP and the underlying mechanisms. The purpose of this study was to investigate the effects of at-risk alcohol use on nighttime BP, urinary catecholamines, and sleep quality in midlife adults.
Methods
A total of 32 midlife men and 30 postmenopausal women, free of major clinical diseases and nonsmokers (age: 58 ± 4; mean ± SD), were included. Among all participants, 22 were currently taking antihypertensive medications. At-risk drinkers were defined as those who had a dried blood spot phosphatidylethanol level ≥20 ng/mL. All participants completed 24-h ambulatory BP monitoring and urine collection to determine nighttime (or asleep) BP and nighttime urinary catecholamine levels. Sleep quality was determined by using the Pittsburgh Sleep Quality Index.
Results
In midlife adults free of antihypertensive medications, at-risk drinkers had a higher nighttime systolic (118 ± 14 vs. 107 ± 14 mmHg, p = 0.02) and diastolic BP (70 ± 9 vs. 62 ± 9 mmHg, p = 0.003) than low-risk drinkers with no between-group differences in sleep quality component scores (p ≥ 0.14). In midlife adults taking antihypertensive medications, no difference in nighttime BP was found between at-risk drinkers and low-risk drinkers (p ≥ 0.68), with a higher score for the “use of sleeping medication” component in high-risk drinkers (p = 0.02). Regardless of antihypertensive medication use, no difference between at-risk drinkers and low-risk drinkers was found in nighttime urinary catecholamine levels (p ≥ 0.19).
Conclusions
Our findings suggest that in midlife adults free of antihypertensive medication use, at-risk alcohol use is associated with an increase in nighttime BP, and the increase in nighttime BP may be mediated by mechanisms other than increased catecholamines and poor sleep quality.
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