基于复用光纤元尖端的圆极仪用于缺血性中风的无标记病理分析。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Neurophotonics Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI:10.1117/1.NPh.12.1.015012
Wenlin Luan, Qingcheng Song, Quancheng Cheng, Chunhua Chen, Xia Yu
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引用次数: 0

摘要

意义:我们提出了一种全过程无标签脑切片筛查的光学技术。该方法具有操作简单、准确度高的优点,可为今后相关疾病的诊断提供方便的依据。目的:其任务之一是提供一种可量化的、可重复的分析方法,以取代或补充传统的定性的、主观的病理分析。方法:提出了一种基于多路光纤元尖端的无标记、灵敏、快速的圆形偏振方法,用于缺血性卒中的数字病理。利用前向散射光偏振信息识别缺血性脑卒中组织轴突分布的病理变化。新设计的四通道光纤元针尖在多路圆偏振法中提供了微型照明。结论:基于多路光纤元针尖的高灵敏度、无标记的圆偏振法为各种疾病的快速数字病理诊断提供了可能。它将通过定量引入一种新的可靠数据模式,在不改变目前建立的流程的情况下,增强数字病理学在未来疾病诊断中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiplexed fiber meta-tip-based circular polarimetry for label-free pathological analysis of ischemic stroke.

Significance: We present an optical technology for a full-process label-free method for brain slice screening. This proposed multiplexed circular polarimetric method has the advantages of simple operation and high accuracy which may provide easily accessible evidence for the future diagnosis of related diseases.

Aim: One of its missions is to provide a quantifiable, reproducible analysis methodology that can replace or supplement traditional qualitative, subjective pathological analysis.

Approach: A label-free, sensitive, and rapid circular polarimetric method based on a multiplexed optical fiber meta-tip is proposed for the digital pathology of ischemic stroke. Polarization information of forward-scattered light is used to identify pathological variations of axon distribution in ischemic stroke tissues. The newly designed optical fiber meta-tip with four channels offers miniature illumination in the multiplexed circular polarimetry method.

Results: Our automated approach achieves more than 90% area under the curve in classifying ischemic stroke brain tissue in around 1 min.

Conclusions: The high-sensitivity and label-free circular polarimetric method based on the multiplexed optical fiber meta-tip renders its potential for rapid digital pathology of various diseases. It will empower the application of digital pathology in future disease diagnosis by quantitatively introducing a new reliable data modality without altering currently established processes.

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来源期刊
Neurophotonics
Neurophotonics Neuroscience-Neuroscience (miscellaneous)
CiteScore
7.20
自引率
11.30%
发文量
114
审稿时长
21 weeks
期刊介绍: At the interface of optics and neuroscience, Neurophotonics is a peer-reviewed journal that covers advances in optical technology applicable to study of the brain and their impact on the basic and clinical neuroscience applications.
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