基于营养预测因子的消化道癌症风险评分的发展:Golestan队列研究中的风险预测模型。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Masoumeh Jabbari, Meisam Barati, Ali Kalhori, Hassan Eini-Zinab, Farid Zayeri, Hossein Poustchi, Akram Pourshams, Azita Hekmatdoost, Reza Malekzadeh
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引用次数: 0

摘要

本研究旨在开发一个非实验室简单和有用的评分系统,以预测伊朗人口的医疗保健和临床框架内发生消化系统癌症的风险。本研究是根据Golestan队列研究收集的数据进行的。从贡巴德市和326个农村招募了49,173名年龄在37-80岁之间的参与者,并于2004年至2021年在伊朗进行了随访。在本研究中,通过饮食预测因子和制定简单实用的评分系统,在伊朗人群中建立了一个预测15年消化道癌症风险的非实验室模型。总共有43550名参与者(25249名女性和18301名男性)被纳入最终分析。采用一致性统计量(C-statistic)和校正图分别评价模型的判别性和校正性。该模型在推导样本(C-statistic: 0.76)和验证样本(C-statistic: 0.70)中都有可接受的区别
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a Digestive Cancer Risk Score Based on Nutritional Predictors: A Risk Prediction Model in the Golestan Cohort Study.

This study aimed to develop a non-laboratory simple and useful scoring system to predict risk of incident digestive cancers within the healthcare and clinical framework in Iranian population. The present study was conducted on the collected data from the Golestan Cohort Study. A total of 49,173 participants, aged 37-80 years, were recruited from Gonbad City and 326 rural villages and were followed from 2004 to 2021 in Iran. A non-laboratory model for prediction of the 15-year risk of digestive cancers by means of dietary predictors and formulating a simple and useful scoring system in Iranian population was done in this study. A total of 43550 participants (25249 women and 18301 men) were included in the final analysis. The model's discrimination and calibration were assessed by concordance statistic (C-statistic) and calibration plot, respectively. The model had an acceptable discrimination in both derivation (C-statistic: 0.76) and validation (C-statistic: 0.70) samples (p < 0.001). Also, the calibration of model in derivation and validation datasets was 0.88 and 0.91, respectively. As an assessment tool, the established simple and practical nutritional risk score is suitable for motivating at-risk individuals to change lifestyles and dietary patterns to reduce future risks and prevent health problems.

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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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