以鸡胚模型为工具探讨酒精对心血管发育的影响。

IF 1.7 4区 教育学 Q2 EDUCATION, SCIENTIFIC DISCIPLINES
Advances in Physiology Education Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI:10.1152/advan.00195.2024
Declan McLaughlin, Aisling Keane, Joe Quinn, Nuala Tipping
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引用次数: 0

摘要

在发展过程中,生理学和解剖学之间的相互关系是具有挑战性的,因为学习者必须了解生理过程和解剖结构如何随着时间的推移而变化。此外,结构和功能之间的动态关系往往被隐藏,很大程度上是由于胚胎在高阶生物中不可接近。这使得学生很难理解正常的复杂平衡或解释发育中断对正常胚胎发育的生理后果。在本文中,探讨了鸡胚模型在实际课堂中的适用性,因为学生可以在受控的蛋环境中直接观察发育过程。本文描述了开发鸡胚胎模型所涉及的实际方法,然后进行了扩展,以演示如何利用该模型来展示心血管系统的发展。该模型进一步适用于探索致畸干扰物(如乙醇)对正常心血管过程的影响,并强调产前酒精暴露如何导致与胎儿酒精综合征(FAS)相关的心血管异常,如室间隔缺陷和心脏生理改变。在课堂上,学生可以直接观察小鸡受精后0- 8天的发育情况。计算可测量的结果,如间隔厚度的比较,同时提供问题和答案,以激发学生围绕功能变化和母亲饮酒的影响进行讨论,作为资源材料。概述的方法使用相对便宜的材料,需要很少的空间,使其成为一种经济有效的教育工具,以支持学生学习胚胎学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The chick embryo model as an educational tool to explore the effect of alcohol on cardiovascular development.

In development, the interrelationship between physiology and anatomy is challenging as learners must appreciate how physiological processes and anatomical structures change over time. In addition, the dynamic relationships between structure and function are often concealed largely due to the inaccessibility of the embryo in higher-order organisms. This makes it difficult for students to appreciate normal intricate balances or interpret the physiological consequences of developmental disruptions to normal embryological development. In this paper, the applicability of the chick embryo model for use in practical classes is explored as students can observe developmental processes firsthand within a controlled in ovo environment. Practical approaches involved in developing the chick embryo model are described and then expanded to demonstrate how the model can be utilized to showcase cardiovascular system development as an example. The model is further adapted to explore the effect of teratogenic disruptors such as ethanol on normal cardiovascular processes and highlights how prenatal alcohol exposure results in cardiovascular anomalies associated with fetal alcohol syndrome, such as septal defects and altered cardiac physiology. In class, students can directly observe chick development from 0 to 8 days postfertilization. Measurable outcomes, such as comparisons in septal thickness, are calculated, while questions and answers to stimulate student discussion around functional changes and the impact of maternal consumption of alcohol are provided as resource material. The method outlined uses relatively inexpensive materials and requires little space, making it a cost-effective educational tool to support student learning of embryology.NEW & NOTEWORTHY This study explores the use of the chick embryo model as a teaching aid to illustrate connections between anatomy and physiology during development. Providing direct observation opportunities, the model allows students to witness organ formation and the impact of teratogens, focusing on cardiovascular abnormalities associated with fetal alcohol syndrome. The paper outlines practical methodologies to assess developmental outcomes. Its adaptability, affordability, and ability to spark discussions make the model a valuable resource for diverse educational environments.

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来源期刊
CiteScore
3.40
自引率
19.00%
发文量
100
审稿时长
>12 weeks
期刊介绍: Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms. Submissions that evaluate new technologies for teaching and research, and educational pedagogy, are especially welcome. The audience for the journal includes educators at all levels: K–12, undergraduate, graduate, and professional programs.
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