Agnė Okulevičiūtė, Sigitas Chmieliauskas, Gabija Laubner-Sakalauskienė, Robertas Badaras, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė
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The study analyzed ethyl alcohol concentrations in blood, urine, muscle and bile. Toxicological data were processed using R commander statistical software. The study aimed to assess the changes, patterns, and correlations of ethyl alcohol concentrations in different body fluids after death.</p><p><strong>Results: </strong>When the ethyl alcohol concentrations of the different body fluids from the autopsies were evaluated, the urine ethyl alcohol concentration was in 86% cases higher than the blood ethyl alcohol concentration, with a mean difference of 0.51‰. There is a strong correlation between blood and urine ethyl alcohol concentrations, r = 0.93, p < 0.05. The ethyl alcohol concentration in muscle was 75% higher than in blood with a mean difference of 0.06‰. Ethyl alcohol concentration in bile was 90% higher than in blood with a mean difference of 0.14‰. The difference between ethyl alcohol concentrations in bile and muscle was not significant, with a mean difference of 0.07‰.</p><p><strong>Conclusions: </strong>In addition to blood and urine, muscle and bile samples may be taken at autopsy to detect ethyl alcohol. The results of the study show that there may be differences in the levels of ethyl alcohol in different body fluids after death. 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引用次数: 0
摘要
体液中乙醇浓度的测定是法医实践中的一项重要调查。为了避免死后血液酒精浓度的变化，测试物质必须在富含氟化钠或草酸钾的特殊介质中运输。在解释体内浓度的变化时，不仅要评估血液，还要评估其他体液或组织，这一点很重要。材料和方法：2016年至2023年进行回顾性研究，评估立陶宛国家法医服务的非连续378例尸检数据。该研究分析了血液、尿液、肌肉和胆汁中的酒精浓度。毒理学资料采用R commander统计软件处理。该研究旨在评估死后不同体液中乙醇浓度的变化、模式和相关性。结果：对尸体不同体液中乙醇浓度进行测定时，86%的尸体尿液中乙醇浓度高于血液中乙醇浓度，平均差值为0.51‰。血、尿乙醇浓度相关性强，r = 0.93, p < 0.05。肌肉中的酒精浓度比血液中的酒精浓度高75%，平均差值为0.06‰。胆汁中乙醇浓度比血液中高90%，平均差值为0.14‰。胆汁和肌肉中乙醇浓度的差异不显著，平均差异为0.07‰。结论：除了血液和尿液，肌肉和胆汁样本可以在尸检中检测乙醇。研究结果表明，死后不同体液中的酒精含量可能存在差异。因此，这些数据对于在临床和法医实践中评估乙醇浓度非常重要。
Postmortem Analysis of Ethyl Alcohol Concentration in Blood, Urine, Muscle and Bile.
Introduction: The determination of ethyl alcohol concentration in body fluids is an important investigation in forensic practice. To avoid postmortem changes in blood alcohol concentration, the test substance must be transported in special media enriched with sodium fluoride or potassium oxalate. When interpreting changes in concentrations in the body, it is important to assess not only the blood but also other body fluids or tissues.
Materials and methods: A retrospective study was conducted from 2016 to 2023, evaluating data from nonconsecutive 378 autopsies from the State Forensic Medical Service of Lithuania. The study analyzed ethyl alcohol concentrations in blood, urine, muscle and bile. Toxicological data were processed using R commander statistical software. The study aimed to assess the changes, patterns, and correlations of ethyl alcohol concentrations in different body fluids after death.
Results: When the ethyl alcohol concentrations of the different body fluids from the autopsies were evaluated, the urine ethyl alcohol concentration was in 86% cases higher than the blood ethyl alcohol concentration, with a mean difference of 0.51‰. There is a strong correlation between blood and urine ethyl alcohol concentrations, r = 0.93, p < 0.05. The ethyl alcohol concentration in muscle was 75% higher than in blood with a mean difference of 0.06‰. Ethyl alcohol concentration in bile was 90% higher than in blood with a mean difference of 0.14‰. The difference between ethyl alcohol concentrations in bile and muscle was not significant, with a mean difference of 0.07‰.
Conclusions: In addition to blood and urine, muscle and bile samples may be taken at autopsy to detect ethyl alcohol. The results of the study show that there may be differences in the levels of ethyl alcohol in different body fluids after death. These data are therefore important for the assessment of ethyl alcohol concentrations in both clinical and forensic practice.
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