{"title":"剂量依赖性急性肝炎与高剂量甲氨蝶呤的施用有关。","authors":"A K Banerjee, S Lakhani, M Vincent, P Selby","doi":"10.1177/096032718800700608","DOIUrl":null,"url":null,"abstract":"The association between long-term methotrexate administration and progressive liver disease is well established. The common complications are liver fibrosis and cirrhosis but these changes are not associated with a rise in liver transaminases.1 We report a case of a young girl who developed a dosedependent acute hepatitis following high dose methotrexate (MTX) treatment for osteosarcoma.","PeriodicalId":13194,"journal":{"name":"Human toxicology","volume":"7 6","pages":"561-2"},"PeriodicalIF":0.0000,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/096032718800700608","citationCount":"17","resultStr":"{\"title\":\"Dose-dependent acute hepatitis associated with administration of high dose methotrexate.\",\"authors\":\"A K Banerjee, S Lakhani, M Vincent, P Selby\",\"doi\":\"10.1177/096032718800700608\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The association between long-term methotrexate administration and progressive liver disease is well established. The common complications are liver fibrosis and cirrhosis but these changes are not associated with a rise in liver transaminases.1 We report a case of a young girl who developed a dosedependent acute hepatitis following high dose methotrexate (MTX) treatment for osteosarcoma.\",\"PeriodicalId\":13194,\"journal\":{\"name\":\"Human toxicology\",\"volume\":\"7 6\",\"pages\":\"561-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/096032718800700608\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/096032718800700608\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/096032718800700608","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dose-dependent acute hepatitis associated with administration of high dose methotrexate.
The association between long-term methotrexate administration and progressive liver disease is well established. The common complications are liver fibrosis and cirrhosis but these changes are not associated with a rise in liver transaminases.1 We report a case of a young girl who developed a dosedependent acute hepatitis following high dose methotrexate (MTX) treatment for osteosarcoma.
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