Bo Zuo, Binhe Yu, Pengwei Wang, Chong Zhang, Chenhao Zhao, Yujing Sun, Sizhi Ai
{"title":"循环脂肪酸在失眠对心力衰竭的影响中的作用：一项两步、两样本孟德尔随机研究。","authors":"Bo Zuo, Binhe Yu, Pengwei Wang, Chong Zhang, Chenhao Zhao, Yujing Sun, Sizhi Ai","doi":"10.2147/NSS.S471466","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in the occurrence and development of heart failure. It is unclear whether fatty acids play roles in the causal association between insomnia and heart failure. This study aims to investigate the mediating role of fatty acids in the association between insomnia and heart failure.</p><p><strong>Methods: </strong>We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators and outcomes. Summary data obtained from genome-wide association studies for insomnia, proposed fatty acid mediators and heart failure were used in this study. The overall effect of insomnia on heart failure includes direct and indirect effects.</p><p><strong>Results: </strong>Genetically predicted insomnia has a significant causal effect on circulating total fatty acids, saturated fatty acids, monounsaturated fatty acids and omega-3 fatty acids. In addition, different circulating fatty acids have no causal effect on insomnia incidence. A significant positive correlation between genetic predicted insomnia and heart failure (OR = 1.10, 95% CI: 1.06-1.14, <i>P</i><0.001) was observed. Finally, we found that circulating fatty acids play a mediating role in the causal association between insomnia and heart failure. Total fatty acids, saturated fatty acids and monounsaturated fatty acids explained 3% (95% CI: 0%-7.5%), 3% (95% CI: -1.1%-7.5%), 4% (95% CI: 0%- 9.7%) of the overall effect of insomnia on heart failure, respectively.</p><p><strong>Conclusion: </strong>These results support circulating fatty acids as potential mediators in the causal association between insomnia and heart failure.</p>","PeriodicalId":18896,"journal":{"name":"Nature and Science of Sleep","volume":"17 ","pages":"391-399"},"PeriodicalIF":3.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890014/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of Circulating Fatty Acids in Mediating the Effect of Insomnia on Heart Failure: A Two-Step, Two-Sample Mendelian Randomization Study.\",\"authors\":\"Bo Zuo, Binhe Yu, Pengwei Wang, Chong Zhang, Chenhao Zhao, Yujing Sun, Sizhi Ai\",\"doi\":\"10.2147/NSS.S471466\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in the occurrence and development of heart failure. It is unclear whether fatty acids play roles in the causal association between insomnia and heart failure. This study aims to investigate the mediating role of fatty acids in the association between insomnia and heart failure.</p><p><strong>Methods: </strong>We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators and outcomes. Summary data obtained from genome-wide association studies for insomnia, proposed fatty acid mediators and heart failure were used in this study. The overall effect of insomnia on heart failure includes direct and indirect effects.</p><p><strong>Results: </strong>Genetically predicted insomnia has a significant causal effect on circulating total fatty acids, saturated fatty acids, monounsaturated fatty acids and omega-3 fatty acids. In addition, different circulating fatty acids have no causal effect on insomnia incidence. A significant positive correlation between genetic predicted insomnia and heart failure (OR = 1.10, 95% CI: 1.06-1.14, <i>P</i><0.001) was observed. Finally, we found that circulating fatty acids play a mediating role in the causal association between insomnia and heart failure. Total fatty acids, saturated fatty acids and monounsaturated fatty acids explained 3% (95% CI: 0%-7.5%), 3% (95% CI: -1.1%-7.5%), 4% (95% CI: 0%- 9.7%) of the overall effect of insomnia on heart failure, respectively.</p><p><strong>Conclusion: </strong>These results support circulating fatty acids as potential mediators in the causal association between insomnia and heart failure.</p>\",\"PeriodicalId\":18896,\"journal\":{\"name\":\"Nature and Science of Sleep\",\"volume\":\"17 \",\"pages\":\"391-399\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890014/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature and Science of Sleep\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/NSS.S471466\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature and Science of Sleep","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/NSS.S471466","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The Role of Circulating Fatty Acids in Mediating the Effect of Insomnia on Heart Failure: A Two-Step, Two-Sample Mendelian Randomization Study.
Purpose: Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in the occurrence and development of heart failure. It is unclear whether fatty acids play roles in the causal association between insomnia and heart failure. This study aims to investigate the mediating role of fatty acids in the association between insomnia and heart failure.
Methods: We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators and outcomes. Summary data obtained from genome-wide association studies for insomnia, proposed fatty acid mediators and heart failure were used in this study. The overall effect of insomnia on heart failure includes direct and indirect effects.
Results: Genetically predicted insomnia has a significant causal effect on circulating total fatty acids, saturated fatty acids, monounsaturated fatty acids and omega-3 fatty acids. In addition, different circulating fatty acids have no causal effect on insomnia incidence. A significant positive correlation between genetic predicted insomnia and heart failure (OR = 1.10, 95% CI: 1.06-1.14, P<0.001) was observed. Finally, we found that circulating fatty acids play a mediating role in the causal association between insomnia and heart failure. Total fatty acids, saturated fatty acids and monounsaturated fatty acids explained 3% (95% CI: 0%-7.5%), 3% (95% CI: -1.1%-7.5%), 4% (95% CI: 0%- 9.7%) of the overall effect of insomnia on heart failure, respectively.
Conclusion: These results support circulating fatty acids as potential mediators in the causal association between insomnia and heart failure.
期刊介绍：
Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep.
Specific topics covered in the journal include:
The functions of sleep in humans and other animals
Physiological and neurophysiological changes with sleep
The genetics of sleep and sleep differences
The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness
Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness
Sleep changes with development and with age
Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause)
The science and nature of dreams
Sleep disorders
Impact of sleep and sleep disorders on health, daytime function and quality of life
Sleep problems secondary to clinical disorders
Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health)
The microbiome and sleep
Chronotherapy
Impact of circadian rhythms on sleep, physiology, cognition and health
Mechanisms controlling circadian rhythms, centrally and peripherally
Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health
Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption
Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms
Epigenetic markers of sleep or circadian disruption.
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