Pengfei Kang, Boju Sun, Jing Hao, Conghui Wang, Xiangmei Chen
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引用次数: 0
摘要
虽然以前的研究已经调查了肾周脂肪对慢性肾脏疾病（CKD）的影响，但尚未有系统的综述和荟萃分析来调查肾周脂肪与慢性肾脏疾病之间的关系。方法：检索PubMed、Scopus、Web of Science、Ovid、Embase、Cochrane Library等6个英文电子数据库，选择报道肾周脂肪与CKD关系的临床研究，检索时间为数据库建立至2024年9月10日。两名研究人员独立筛选了这些研究，并最终比较了文献。Stata(版本16 SE；使用College Station， TX)软件进行统计分析。结果：本荟萃分析共纳入8篇文章，共纳入2576例患者。结果显示，肾周脂肪与CKD之间存在显著相关性(95%CI: 0.48-0.65；P=0.00)，两组间无异质性（I2=31.06%， P=0.18）。亚组分析显示，无论是糖尿病肾病、心功能异常所致肾病，还是原发性CKD，肾周脂肪都与之密切相关。结论：本系统综述和荟萃分析结果显示，肾周脂肪厚度与CKD密切相关。临床医生在诊断和治疗CKD患者时应注意相关指标。
Perirenal Fat and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
Introduction: Although previous studies have investigated the impact of perirenal fat on chronic kidney disease (CKD), there are yet no systematic reviews and meta-analyses to investigate the association between perirenal fat and CKD.
Methods: We searched six English electronic databases including PubMed, Scopus, Web of Science, Ovid, Embase, and the Cochrane Library to select clinical studies that reported the relationship between perirenal fat and CKD, and the search period ranged from the establishment of the database to September 10, 2024. Two researchers independently screened the studies and ultimately compared the literature. Stata (version 16 SE; College Station, TX, USA) software was used for statistical analysis.
Results: A total of eight articles that included 2,576 patients were included in this meta-analysis. The results showed a significant association between perirenal fat and CKD (95% CI: 0.48-0.65, p = 0.00), and no heterogeneity was detected between these two groups (I2 = 31.06%, p = 0.18). Subgroup analysis revealed that whether it is diabetic nephropathy, nephropathy caused by abnormal cardiac function, or primary CKD, perirenal fat is closely related to them.
Conclusion: The results of this systematic review and meta-analysis showed that perirenal fat thickness is closely related to CKD. Clinicians should pay attention to relevant indicators when diagnosing and treating patients with CKD.
期刊介绍：
This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.
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