荷兰-德国北部跨境地区肠球菌和万古霉素耐药屎肠球菌菌血症的时间趋势：一项10年多中心分析（2013-2022）。

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

Journal of global antimicrobial resistance Pub Date : 2025-03-05 DOI:10.1016/j.jgar.2025.02.022

Cansu Cimen , Andreas Voss , Josef Hellkamp , Axel Hamprecht , Matthijs S. Berends

{"title":"荷兰-德国北部跨境地区肠球菌和万古霉素耐药屎肠球菌菌血症的时间趋势：一项10年多中心分析（2013-2022）。","authors":"Cansu Cimen , Andreas Voss , Josef Hellkamp , Axel Hamprecht , Matthijs S. Berends","doi":"10.1016/j.jgar.2025.02.022","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To analyse the trends in occurrence of enterococcal and vancomycin-resistant <em>Enterococcus faecium</em> (VREfm) bacteraemia in the northern Dutch-German cross-border region.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted using positive blood culture results from two university hospitals, the University Medical Centre Groningen (UMCG) and the Klinikum Oldenburg (KOL) between 1 January 2013 to 31 December 2022.</div></div><div><h3>Results</h3><div>Over the 10-y period, 738 enterococcal bacteraemia episodes were observed at KOL and 1091 at UMCG, involving 685 and 999 patients, respectively. <em>E. faecium</em> was the predominant species in both institutions (60.3% at KOL and 60.8% at UMCG). The median age of patients with enterococcal, <em>E. faecium, E. faecalis</em> and VREfm bacteraemia was consistently higher at KOL than at UMCG (<em>p=</em> <em>.029</em>). In both institutions, over half of the enterococcal bacteraemia cases (53.4% at KOL, 55.8% at UMCG) were observed in intensive care units and haematology/oncology wards. From 2018 to 2022, UMCG had higher overall incidence rates of <em>E. faecium</em>, and <em>E. faecalis</em> bacteraemia, while KOL had a significantly higher incidence of VREfm (0.56 vs. 0.05 per 10,000 patient-d, <em>p<</em> <em>.0001</em>). There was a significant upward trend in VREfm bacteraemia cases (<em>p=</em> <em>.01</em>) and in the proportion of VREfm among bacteraemia caused by <em>E. faecium</em> (<em>p=</em> <em>.027</em>) at KOL, but such a trend was not observed at UMCG during the study period.</div></div><div><h3>Conclusions</h3><div>The results reveal a significant difference in VREfm bacteraemia occurrences between a German and Dutch hospital in a cross-border region, reflecting national trends yet showing regional variation.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 187-194"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022)\",\"authors\":\"Cansu Cimen , Andreas Voss , Josef Hellkamp , Axel Hamprecht , Matthijs S. Berends\",\"doi\":\"10.1016/j.jgar.2025.02.022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To analyse the trends in occurrence of enterococcal and vancomycin-resistant <em>Enterococcus faecium</em> (VREfm) bacteraemia in the northern Dutch-German cross-border region.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted using positive blood culture results from two university hospitals, the University Medical Centre Groningen (UMCG) and the Klinikum Oldenburg (KOL) between 1 January 2013 to 31 December 2022.</div></div><div><h3>Results</h3><div>Over the 10-y period, 738 enterococcal bacteraemia episodes were observed at KOL and 1091 at UMCG, involving 685 and 999 patients, respectively. <em>E. faecium</em> was the predominant species in both institutions (60.3% at KOL and 60.8% at UMCG). The median age of patients with enterococcal, <em>E. faecium, E. faecalis</em> and VREfm bacteraemia was consistently higher at KOL than at UMCG (<em>p=</em> <em>.029</em>). In both institutions, over half of the enterococcal bacteraemia cases (53.4% at KOL, 55.8% at UMCG) were observed in intensive care units and haematology/oncology wards. From 2018 to 2022, UMCG had higher overall incidence rates of <em>E. faecium</em>, and <em>E. faecalis</em> bacteraemia, while KOL had a significantly higher incidence of VREfm (0.56 vs. 0.05 per 10,000 patient-d, <em>p<</em> <em>.0001</em>). There was a significant upward trend in VREfm bacteraemia cases (<em>p=</em> <em>.01</em>) and in the proportion of VREfm among bacteraemia caused by <em>E. faecium</em> (<em>p=</em> <em>.027</em>) at KOL, but such a trend was not observed at UMCG during the study period.</div></div><div><h3>Conclusions</h3><div>The results reveal a significant difference in VREfm bacteraemia occurrences between a German and Dutch hospital in a cross-border region, reflecting national trends yet showing regional variation.</div></div>\",\"PeriodicalId\":15936,\"journal\":{\"name\":\"Journal of global antimicrobial resistance\",\"volume\":\"42 \",\"pages\":\"Pages 187-194\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of global antimicrobial resistance\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213716525000578\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of global antimicrobial resistance","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213716525000578","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

目的：分析荷德北部边境地区肠球菌和耐万古霉素屎肠球菌（VREfm）菌血症的发生趋势。方法：采用2013年1月1日至2022年12月31日期间格罗宁根大学医学中心（UMCG）和Klinikum Oldenburg （KOL）两所大学医院的阳性血培养结果进行回顾性横断面研究。结果：10年间，KOL共发生738例肠球菌菌血症，UMCG共发生1091例，分别涉及685例和999例患者。两所机构的优势种均为粪肠杆菌（KOL 60.3%, UMCG 60.8%）。KOL组肠球菌、粪肠球菌、粪肠球菌和VREfm菌血症患者的中位年龄始终高于UMCG组（p = 0.029）。在这两个机构中，半数以上的肠球菌菌血症病例（KOL为53.4%，UMCG为55.8%）发生在重症监护病房和血液科/肿瘤科病房。2018 - 2022年，UMCG的粪肠杆菌和粪肠杆菌血症总发病率较高，而KOL的VREfm发病率显著高于UMCG （0.56 vs. 0.05 / 10,000患者-d， p < 0.0001）。在KOL处，VREfm菌血症病例数（p = 0.01）和VREfm在粪肠杆菌引起的菌血症中的比例（p = 0.027）有显著上升趋势，而在研究期间，UMCG未见此趋势。结论：结果显示德国和荷兰医院在跨境地区的VREfm菌血症发生率存在显著差异，反映了国家趋势，但也表现出地区差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022)

Objective

To analyse the trends in occurrence of enterococcal and vancomycin-resistant Enterococcus faecium (VREfm) bacteraemia in the northern Dutch-German cross-border region.

Methods

A retrospective cross-sectional study was conducted using positive blood culture results from two university hospitals, the University Medical Centre Groningen (UMCG) and the Klinikum Oldenburg (KOL) between 1 January 2013 to 31 December 2022.

Results

Over the 10-y period, 738 enterococcal bacteraemia episodes were observed at KOL and 1091 at UMCG, involving 685 and 999 patients, respectively. E. faecium was the predominant species in both institutions (60.3% at KOL and 60.8% at UMCG). The median age of patients with enterococcal, E. faecium, E. faecalis and VREfm bacteraemia was consistently higher at KOL than at UMCG (p= .029). In both institutions, over half of the enterococcal bacteraemia cases (53.4% at KOL, 55.8% at UMCG) were observed in intensive care units and haematology/oncology wards. From 2018 to 2022, UMCG had higher overall incidence rates of E. faecium, and E. faecalis bacteraemia, while KOL had a significantly higher incidence of VREfm (0.56 vs. 0.05 per 10,000 patient-d, p< .0001). There was a significant upward trend in VREfm bacteraemia cases (p= .01) and in the proportion of VREfm among bacteraemia caused by E. faecium (p= .027) at KOL, but such a trend was not observed at UMCG during the study period.

Conclusions

The results reveal a significant difference in VREfm bacteraemia occurrences between a German and Dutch hospital in a cross-border region, reflecting national trends yet showing regional variation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

8.70

自引率

2.20%

发文量

285

审稿时长

34 weeks

期刊介绍： The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.