C. L. Pappe, J. Maetschker, S. Dujardin, B. Peters, O. Pivovarova-Ramich, F. Kandil, A. Michalsen, C. Breinlinger, N. Steckhan, D. Koppold, H. Dommisch
{"title":"间歇性禁食减少牙龈炎症：一项三组临床试验。","authors":"C. L. Pappe, J. Maetschker, S. Dujardin, B. Peters, O. Pivovarova-Ramich, F. Kandil, A. Michalsen, C. Breinlinger, N. Steckhan, D. Koppold, H. Dommisch","doi":"10.1111/jcpe.14151","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.</p>\n </section>\n \n <section>\n \n <h3> Material and Methods</h3>\n \n <p>All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (<i>n</i> = 22) and CG (<i>n</i> = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.</p>\n </section>\n </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"681-694"},"PeriodicalIF":5.8000,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14151","citationCount":"0","resultStr":"{\"title\":\"Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial\",\"authors\":\"C. L. Pappe, J. Maetschker, S. Dujardin, B. Peters, O. Pivovarova-Ramich, F. Kandil, A. Michalsen, C. Breinlinger, N. Steckhan, D. Koppold, H. Dommisch\",\"doi\":\"10.1111/jcpe.14151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Material and Methods</h3>\\n \\n <p>All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (<i>n</i> = 22) and CG (<i>n</i> = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.</p>\\n </section>\\n </div>\",\"PeriodicalId\":15380,\"journal\":{\"name\":\"Journal of Clinical Periodontology\",\"volume\":\"52 5\",\"pages\":\"681-694\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2025-03-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14151\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Periodontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14151\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14151","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial
Aim
To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.
Material and Methods
All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.
Results
Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (n = 22) and CG (n = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).
Conclusion
This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.
期刊介绍：
Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology.
The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope.
The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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