含γ-内酯的两个新哈利曼类化合物。

IF 1.5 4区 医学 Q4 CHEMISTRY, MEDICINAL
Kanami Watanabe, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
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引用次数: 0

摘要

通过对热带雨林植物大戟科Croton argyratus (Euphorbiaceae)的植物化学研究,分离到两种halimane型二萜:crotargyolides A(1)和B(2),在C-5和C-9处有一个罕见的γ-内酯环,以及一种crotofolene型二萜,3-羟基化crotofolin C (3, crokocrotogenoid A),以及已知的clerodane型二萜,junceic acid(4)和环氧junceic acid(5)。高分辨率(HR)质谱分析和电子圆二色性(ECD)光谱。讨论了提出的由4合成1的生物合成途径。对Crotargyolide A(1)和已知化合物4和5的抗增殖活性进行了评估,对所有测试的肿瘤细胞系均无生长抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Two New Halimanes with a γ-Lactone from Croton argyratus.

The phytochemical investigation of the rainforest plant Croton argyratus (Euphorbiaceae) led to the isolation of two halimane-type diterpenes, crotargyolides A (1) and B (2), with an uncommon γ-lactone ring at C-5 and C-9, together with a crotofolane-type diterpene, 3-hydroxylated crotofolin C (3, crokocrotogenoid A), and the known clerodane diterpenes, junceic acid (4) and epoxyjunceic acid (5). The structures of the newly isolated compounds were elucidated by various NMR techniques, high resolution (HR)MS analysis, and electronic circular dichroism (ECD) spectroscopy. The proposed biosynthetic pathway of 1 from 4 was discussed. Crotargyolide A (1) and known compounds 4 and 5 were evaluated for antiproliferative activity and displayed no growth inhibitory effect toward all tested tumor cell lines.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
132
审稿时长
1.7 months
期刊介绍: The CPB covers various chemical topics in the pharmaceutical and health sciences fields dealing with biologically active compounds, natural products, and medicines, while BPB deals with a wide range of biological topics in the pharmaceutical and health sciences fields including scientific research from basic to clinical studies. For details of their respective scopes, please refer to the submission topic categories below. Topics: Organic chemistry In silico science Inorganic chemistry Pharmacognosy Health statistics Forensic science Biochemistry Pharmacology Pharmaceutical care and science Medicinal chemistry Analytical chemistry Physical pharmacy Natural product chemistry Toxicology Environmental science Molecular and cellular biology Biopharmacy and pharmacokinetics Pharmaceutical education Chemical biology Physical chemistry Pharmaceutical engineering Epidemiology Hygiene Regulatory science Immunology and microbiology Clinical pharmacy Miscellaneous.
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