六步合成及四酮基玻璃体蛋白类似物的上皮-间质过渡抑制活性。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-21 DOI:10.1093/bbb/zbaf030

Yusuke Hanaki, Yasunori Sugiyama, Ryo C Yanagita

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引用次数: 0

摘要

我们以市售的2-甲基-1-四酮为原料，用6步合成了一种玻璃体三甲素类似物，其中a环被苯环取代。与玻璃体铁蛋白D类似，这种类似物抑制酚酯诱导的上皮-间质转化。这种基于四酮的结构简化策略不仅适用于玻璃体叶酸的研究，也适用于其他卤烷型二萜的研究。

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Six-step synthesis and epithelial-mesenchymal transition-inhibitory activity of a tetralone-based vitetrifolin analog.

We synthesized a vitetrifolin analog in which the A-ring was replaced with a benzene ring, in 6 steps from commercially available 2-methyl-1-tetralone. Similarly to vitetrifolin D, this analog suppressed the phorbol ester-induced epithelial-mesenchymal transition. This tetralone-based structural simplification strategy is expected to be applicable to studies on not only vitetrifolins but also other halimane-type diterpenoids.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).