增强的社会互动通过保持突触数量来保护认知。

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-06 DOI:10.1016/j.brainres.2025.149552

Cunyi Xu

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引用次数: 0

摘要

背景：根据NIA-AA指南，通过ABC评分诊断为中度(I)或高(H)的病理诊断为病理性阿尔茨海默病（AD）。多项研究表明，一些病理诊断为AD的个体在其一生中保持正常的认知功能，这里定义为弹性AD （rAD）。与以AD病理诊断和痴呆为特征的典型AD （tAD）相比，rAD脑在AD病理上没有显著差异，但突触数量增加。迄今为止，关于AD的流行病学和保护因素的系统报道有限。方法：本研究调查了来自多个全球中心的报告，以估计病理性AD人群中rAD的患病率。基于PUMC人类脑库，我分析了病理性AD中与痴呆严重程度相关的危险因素和基因突变。此外，我们还利用小鼠模型来探索增强社交互动对病理性AD认知功能的保护作用。结果：多个全球队列分析显示，rAD占病理性AD病例的25- 36% %。PUMC人脑银行的分析表明，病理性AD痴呆的严重程度与年龄和性别无关。然而，tAD组的社会孤立率明显更高。遗传分析表明TREM2 rs2234255 GG > CC和APP rs281865161 TC > GG可能是病理性AD认知功能障碍的危险变异，而CLU rs9331896 CC > TT可能是认知弹性的保护变异。在5只 × FAD小鼠中，增加的社交互动没有显著改变Aβ病理进展，但减少了突触丧失，从而改善了认知功能。结论：这些研究结果表明，促进老年人的情感护理和社会互动可能有助于减缓AD患者的认知能力下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enhanced social interaction protects cognition by preserving synapse numbers

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Enhanced social interaction protects cognition by preserving synapse numbers

Background

According to the NIA-AA guidelines, pathological diagnosis as Intermedia (I) or High (H) via ABC scores qualifies as pathological Alzheimer’s disease (AD). Multiple studies indicated that some individuals, while pathologically diagnosed with AD, maintain normal cognitive function during their lifetime, here defined as resilient AD (rAD). In contrast to typical AD (tAD), characterized by both pathological AD diagnosis and dementia, rAD brains exhibited no significant differences in AD pathology but showed increased synapse numbers. To date, there is limited systematic reporting on the epidemiology and protective factors for rAD.

Methods

This study surveyed reports from multiple global centers to estimate the prevalence of rAD within the pathological AD population. Based on the PUMC Human Brain Bank, I analyzed risk factors and gene mutations associated with dementia severity in pathological AD. Additionally, mouse models were employed to explore the protective effects of enhanced social interaction on cognitive function in pathological AD.

Results

Analysis of multiple global cohorts revealed that rAD accounted for 25–36 % of pathological AD cases. Analysis of the PUMC Human Brain Bank indicated that the severity of dementia in pathological AD was not associated with age or gender. However, the tAD group showed a significantly higher prevalence of social isolation. Genetic analysis suggested that TREM2 rs2234255 GG > CC and APP rs281865161 TC > GG may be risk variants for cognitive impairment in pathological AD, while CLU rs9331896 CC > TT may serve as a protective variant for cognitive resilience. In 5 × FAD mice, increased social interaction did not significantly alter Aβ pathology progression but reduced synaptic loss, thereby improving cognitive function.

Conclusion

These findings suggested that promoting emotional care and social interaction for the elderly may help slow cognitive decline in AD patients.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.