一种新型dmsp型两性离子的合成及表面引发RAFT法在PET表面的构建。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-04-14 DOI:10.1021/acs.biomac.4c01470

Yu Sun , Yushuang Shang , Xinyu Zhang, Zhaoyan Ge, Fengni Liu, Jian Shen, Jiang Yuan

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引用次数: 0

摘要

模仿丙酸二甲基亚砜（DMSP）的结构，以l-半胱氨酸为原料，分三步合成了一种新型两性离子单体n -甲基丙烯酰s -甲基l-半胱氨酸甲基磺酸盐（NMASMCMS）。通过表面引发的可逆加成-破碎链转移（SI-RAFT）聚合，在PET薄片上构建了聚（NMASMCMS）刷。通过水接触角（WCA）、衰减全反射傅里叶变换红外光谱（ATR-FTIR）、x射线光电子能谱（XPS）和原子力显微镜（AFM）表征了其物理和化学结构。聚合物刷接枝片材（PET-B）具有良好的亲水性和高润滑性。此外，PET-B薄片具有优异的防污和血液相容性，具有低蛋白质吸附、细菌粘附、血小板粘附和溶血作用。

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Synthesis of a Novel DMSP-Typed Zwitterion and Construction on PET Surface via Surface-Initiated RAFT Method

Mimicked by the structure of dimethyl sulfoxide propionate (DMSP), a novel zwitterion monomer of N-methylacryloyl S-methyl l-cysteine methyl sulfonium salt (NMASMCMS) was synthesized and characterized for the first time through three steps using l-cysteine as a starting material. Poly(NMASMCMS) brushes were constructed on PET sheets via surface-initiated reversible addition–fragmentation chain-transfer (SI-RAFT) polymerization. The physical and chemical structures were characterized by water contact angle (WCA), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The polymer brush grafted sheets (PET-B) had good hydrophilicity and high lubricity. Moreover, PET-B sheets exhibited excellent antifouling and hemocompatible properties with low protein adsorption, bacterial adhesion, platelet adhesion, and hemolysis.

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.