{"title":"金属化合物在医学中的应用","authors":"E. R. Milaeva","doi":"10.1134/S1070328424600815","DOIUrl":null,"url":null,"abstract":"<p>This review is devoted to inorganic medicinal chemistry, a new interdisciplinary research area that is vigorously developed now as a part of medicinal chemistry. The review describes the metal-containing therapeutic and diagnostic agents present in the global pharmaceutical market and considers the main principles of the design of metal-based drugs. The material reflects the most recent achievements in the field of inorganic medicinal chemistry: the principles of molecular design of drugs based on metal compounds, study of their chemical reactivity in biological environment and mechanisms of pharmacological action, and analysis of the structure–activity relationships. Considerable attention is paid to the biological targets of metal-based drugs. The review is intended for a wide range of researchers, teachers, and students as well as all specialists interested in drug development.</p>","PeriodicalId":759,"journal":{"name":"Russian Journal of Coordination Chemistry","volume":"50 12","pages":"1043 - 1123"},"PeriodicalIF":1.1000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of Metal Compounds in Medicine\",\"authors\":\"E. R. Milaeva\",\"doi\":\"10.1134/S1070328424600815\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This review is devoted to inorganic medicinal chemistry, a new interdisciplinary research area that is vigorously developed now as a part of medicinal chemistry. The review describes the metal-containing therapeutic and diagnostic agents present in the global pharmaceutical market and considers the main principles of the design of metal-based drugs. The material reflects the most recent achievements in the field of inorganic medicinal chemistry: the principles of molecular design of drugs based on metal compounds, study of their chemical reactivity in biological environment and mechanisms of pharmacological action, and analysis of the structure–activity relationships. Considerable attention is paid to the biological targets of metal-based drugs. The review is intended for a wide range of researchers, teachers, and students as well as all specialists interested in drug development.</p>\",\"PeriodicalId\":759,\"journal\":{\"name\":\"Russian Journal of Coordination Chemistry\",\"volume\":\"50 12\",\"pages\":\"1043 - 1123\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Coordination Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070328424600815\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Coordination Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070328424600815","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
This review is devoted to inorganic medicinal chemistry, a new interdisciplinary research area that is vigorously developed now as a part of medicinal chemistry. The review describes the metal-containing therapeutic and diagnostic agents present in the global pharmaceutical market and considers the main principles of the design of metal-based drugs. The material reflects the most recent achievements in the field of inorganic medicinal chemistry: the principles of molecular design of drugs based on metal compounds, study of their chemical reactivity in biological environment and mechanisms of pharmacological action, and analysis of the structure–activity relationships. Considerable attention is paid to the biological targets of metal-based drugs. The review is intended for a wide range of researchers, teachers, and students as well as all specialists interested in drug development.
期刊介绍：
Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.
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