非转基因RNAi技术在植物病毒病可持续控制中的研究进展

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Greeshma Varghese, Puja Dey, Munmi Borah
{"title":"非转基因RNAi技术在植物病毒病可持续控制中的研究进展","authors":"Greeshma Varghese, Puja Dey, Munmi Borah","doi":"10.1007/s11033-025-10376-8","DOIUrl":null,"url":null,"abstract":"<p><p>Viruses are a major cause of plant disease with an estimated annual economic impact of over $30 billion. They account for nearly 50% of the pathogens responsible for emerging and re-emerging plant diseases worldwide. To confer resistance against these diseases RNA interference (RNAi) technology can be employed. Designing silencing molecules like dsRNA homologous to the viral genome has been the most common non-transgenic method to induce RNAi mediated resistance in plants. dsRNAs are carefully tailored and produced considering factors such as the type of virus, target genomic region, dsRNA size, and method of application to maximise their efficiency. With the advent of new technologies like nano-platforms, a sustainable carrier can be developed to deliver these molecules, enhancing their stability and its bioavailability. This innovative technology faces regulatory debates globally and lacks legislation for commercialisation. But this is an eco-friendly alternative to conventional pesticides that can revolutionize the future of plant viral disease management, providing a bio-safe and an evergreen solution.</p>","PeriodicalId":18755,"journal":{"name":"Molecular Biology Reports","volume":"52 1","pages":"293"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-transgenic RNAi strategies for sustainable plant viral disease control: a review.\",\"authors\":\"Greeshma Varghese, Puja Dey, Munmi Borah\",\"doi\":\"10.1007/s11033-025-10376-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Viruses are a major cause of plant disease with an estimated annual economic impact of over $30 billion. They account for nearly 50% of the pathogens responsible for emerging and re-emerging plant diseases worldwide. To confer resistance against these diseases RNA interference (RNAi) technology can be employed. Designing silencing molecules like dsRNA homologous to the viral genome has been the most common non-transgenic method to induce RNAi mediated resistance in plants. dsRNAs are carefully tailored and produced considering factors such as the type of virus, target genomic region, dsRNA size, and method of application to maximise their efficiency. With the advent of new technologies like nano-platforms, a sustainable carrier can be developed to deliver these molecules, enhancing their stability and its bioavailability. This innovative technology faces regulatory debates globally and lacks legislation for commercialisation. But this is an eco-friendly alternative to conventional pesticides that can revolutionize the future of plant viral disease management, providing a bio-safe and an evergreen solution.</p>\",\"PeriodicalId\":18755,\"journal\":{\"name\":\"Molecular Biology Reports\",\"volume\":\"52 1\",\"pages\":\"293\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-03-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Biology Reports\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11033-025-10376-8\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biology Reports","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11033-025-10376-8","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

病毒是植物病害的主要原因,估计每年造成的经济影响超过300亿美元。它们占全世界新出现和再出现的植物疾病病原体的近50%。为了获得对这些疾病的抵抗力,可以使用RNA干扰(RNAi)技术。设计与病毒基因组同源的沉默分子,如dsRNA,是诱导植物RNAi介导抗性的最常用的非转基因方法。考虑到诸如病毒类型、目标基因组区域、dsRNA大小和应用方法等因素,精心定制和生产dsRNA,以最大限度地提高其效率。随着纳米平台等新技术的出现,可以开发出一种可持续的载体来输送这些分子,提高它们的稳定性和生物利用度。这种创新技术在全球范围内面临监管辩论,缺乏商业化立法。但这是传统农药的一种环保替代品,可以彻底改变植物病毒病管理的未来,提供一种生物安全且常绿的解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-transgenic RNAi strategies for sustainable plant viral disease control: a review.

Viruses are a major cause of plant disease with an estimated annual economic impact of over $30 billion. They account for nearly 50% of the pathogens responsible for emerging and re-emerging plant diseases worldwide. To confer resistance against these diseases RNA interference (RNAi) technology can be employed. Designing silencing molecules like dsRNA homologous to the viral genome has been the most common non-transgenic method to induce RNAi mediated resistance in plants. dsRNAs are carefully tailored and produced considering factors such as the type of virus, target genomic region, dsRNA size, and method of application to maximise their efficiency. With the advent of new technologies like nano-platforms, a sustainable carrier can be developed to deliver these molecules, enhancing their stability and its bioavailability. This innovative technology faces regulatory debates globally and lacks legislation for commercialisation. But this is an eco-friendly alternative to conventional pesticides that can revolutionize the future of plant viral disease management, providing a bio-safe and an evergreen solution.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Molecular Biology Reports
Molecular Biology Reports 生物-生化与分子生物学
CiteScore
5.00
自引率
0.00%
发文量
1048
审稿时长
5.6 months
期刊介绍: Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信