Ni(ii)/ spirobox催化吲哚与硝基烯的不对称Friedel-Crafts烷基化反应

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2025-03-10 DOI:10.1039/D4RA08471C

Yanshun Li, Shiqin Sun, Luzhen Jiao, Nanxing Gao and Guorui Cao

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引用次数: 0

摘要

手性spiroBox配体镍配合物催化吲哚与硝基烯的Friedel-Crafts烷基化反应。在广泛的底物范围内获得了优异的产率（高达99%）和对映体过量（ee）值（高达97%）。该催化体系可方便地合成具有高收率和对映选择性的光学活性的2-吲哚-1-硝基衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ni(ii)/spiroBox-catalyzed asymmetric Friedel–Crafts alkylation of indoles with nitroalkenes†

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Ni(ii)/spiroBox-catalyzed asymmetric Friedel–Crafts alkylation of indoles with nitroalkenes†

Nickel complexes of chiral spiroBox ligand catalyzed Friedel–Crafts alkylation reaction of indoles with nitroalkenes. Excellent yields (up to 99%) and enantiomeric excess (ee) values (up to 97%) were obtained with a broad scope of substrates. This catalytic system provides a facile synthesis of optically active 2-indolyl-1-nitro derivatives with high yield and enantioselectivity.

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来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.