工程功能导电水凝胶在心肌梗死修复中的靶向治疗

IF 18 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Qianqian Lv , Dandan Zhou , Yutong He , Tao Xu , Xiaozhong Qiu , Junwei Zeng
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引用次数: 0

摘要

心肌梗死(MI)的特点是心肌细胞再生不足,导致显著的发病率和死亡率。当代的治疗方式,虽然减轻了缺血效应,但未能重建受损的心肌内的机电耦合。新出现的证据支持导电水凝胶(ECHs)通过恢复梗死组织的导电微环境来促进心肌梗死后心功能恢复的作用。这篇综合综述描述了基于其组成导电材料的ECHs分类。它还概括了ech介导的MI修复的流行研究趋势,包括创新的设计范例和微环境敏感策略。该审查还提供了各种植入技术的关键评价,强调了对随之而来的考虑的彻底检查。它阐明了水凝胶在心肌修复中发挥有益作用的机制基础,即通过增强机械和电完整性,发挥抗炎作用,促进血管生成和减少不利的重塑过程。此外,该综述涉及优化ECH功能以实现心肌梗死后良好修复效果的紧迫挑战。本文最后对ECH支架的发展进行了展望,主张采用一种整合多方面物理化学特性的定制方法,以满足个性化医疗的细微差别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair

Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair
Myocardial infarction (MI) is characterized by a paucity of cardiomyocyte regeneration, leading to significant morbidity and mortality. Contemporary therapeutic modalities, while mitigating ischemic effects, fail to reconstitute the impaired electromechanical coupling within the infracted myocardium. Emerging evidence supports the utility of electroconductive hydrogels (ECHs) in facilitating post-MI cardiac function recovery by restoring the conductive microenvironment of the infarcted tissue. This comprehensive review delineates the taxonomy of ECHs predicated on their constituent conductive materials. It also encapsulates prevailing research trends in ECH-mediated MI repair, encompassing innovative design paradigms and microenvironment-sensitive strategies. The review also provides a critical appraisal of various implantation techniques, underscored by a thorough examination of the attendant considerations. It elucidates the mechanistic underpinnings by which hydrogels exert salutary effects on myocardial repair, namely by augmenting mechanical and electrical integrity, exerting anti-inflammatory actions, fostering angiogenesis, and curtailing adverse remodeling processes. Furthermore, the review engages with the pressing challenge of optimizing ECH functionality to achieve superior reparative outcomes post-MI. The discourse concludes with an anticipatory perspective on the evolution of ECH scaffolds, advocating for a tailored approach that integrates multifaceted physicochemical properties to cater to the nuances of personalized medicine.
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来源期刊
Bioactive Materials
Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
28.00
自引率
6.30%
发文量
436
审稿时长
20 days
期刊介绍: Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.
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