肾病综合征的特殊表现:双侧大面积肺栓塞。

IF 1.2 4区 医学 Q4 HEMATOLOGY
Blood Coagulation & Fibrinolysis Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI:10.1097/MBC.0000000000001353
Büşra Daştan İnce, Zeynelabidin Ozturk, Nilgün Eroğlu, Hasibe Gökçe Çinar, Bahriye Uzun Kenan, Ali Fettah
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引用次数: 0

摘要

静脉血栓栓塞(TE)和动脉血栓栓塞在儿童中是罕见的,但可以引起严重的发病率和死亡率。住院儿童TE发病率为每10万人8.6-57例,普通儿科发病率为每10万人0.14-0.9例。儿童肾病综合征(NS)患者发生TE的风险增加。儿童NS患者血栓栓塞并发症的发生率约为3%。在这里,我们报告一个儿童患者,提出了巨大的双侧肺栓塞(PE),其基础条件是NS。在临床病程开始时,临床表现归因于心力衰竭,因此,NS的诊断和治疗被推迟。基于本病例,我们认为临床医生应该考虑小儿PE患者出现低白蛋白血症、弥漫性水肿和大量蛋白尿时的NS,及时开始NS治疗并同时给予TE治疗可以产生积极的结果。我们进一步认为,诊断为PE并伴有低白蛋白血症、全身性水肿和大量蛋白尿的儿科患者应考虑患有NS,并且应立即开始NS治疗,并与TE治疗同时进行,以获得阳性结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An exceptional presentation of nephrotic syndrome: bilateral massive pulmonary embolism.

Venous thromboembolism (TE) and arterial TE are rare in children, but can cause severe morbidity and mortality. The incidence of TE is 8.6-57 per 100 000 among hospitalized children and 0.14-0.9 per 100 000 in the general pediatric population. The risk of TE is increased in pediatric nephrotic syndrome (NS) patients. The incidence of thromboembolic complications in pediatric NS patients is approximately 3%. Herein we report a pediatric patient that presented with massive bilateral pulmonary embolism (PE) in whom the underlying condition was NS. At the onset of the clinical course the clinical findings were attributed to heart failure and, therefore, the diagnosis and treatment of NS was delayed. Based on the presented case, we think that clinicians should consider NS in pediatric patients with PE when hypoalbuminemia, diffuse edema, and massive proteinuria are present, and that timely initiation of NS treatment and concomitant administration of TE treatment can yield positive results. We further think that pediatric patients diagnosed with PE that have concomitant hypoalbuminemia, generalized edema, and massive proteinuria should be considered to have NS and that treatment for NS should be started without delay and concomitantly with TE treatment in order to achieve a positive result.

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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components
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