以前非法雄激素使用者间质细胞功能障碍的特征。

IF 5.1 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Yeliz Bulut, Niels Brandt-Jacobsen, Rasmus Madsen, Mario Thevis, Jan Frystyk, Jakob Albrethsen, Niels Jørgensen, Anders Juul, Caroline Kistorp, Jon Jarløv Rasmussen
{"title":"以前非法雄激素使用者间质细胞功能障碍的特征。","authors":"Yeliz Bulut, Niels Brandt-Jacobsen, Rasmus Madsen, Mario Thevis, Jan Frystyk, Jakob Albrethsen, Niels Jørgensen, Anders Juul, Caroline Kistorp, Jon Jarløv Rasmussen","doi":"10.1210/clinem/dgaf157","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>A few studies have explored the impairment of pituitary gonadotroph and Leydig cell function in men who recently ceased illicit androgen use, as assessed by stimulation tests. However, the capacity of the pituitary-testis axis in previous users who discontinued androgen use years ago remains unclear. This study evaluated the pituitary-testis-axis capacity in previous illicit androgen users and nonusers.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of recreational strength training men with (n = 30) and without (n = 26) a history of illicit androgen use. Previous users were subdivided into 2 subgroups based on detectable (group 1, n = 17) and undetectable (group 2, n = 13) performance-enhancing drugs in the urine.We performed gonadotropin-releasing hormone and human chorionic gonadotropin (hCG) stimulation tests. Serum LH was measured with immunoassay, total testosterone, and insulin-like factor 3 with liquid chromatography-tandem mass spectrometry. Sexual function was assessed using the 15-question International Index of Erectile Function questionnaire.</p><p><strong>Results: </strong>Elapsed duration since androgen cessation, geometric mean (95% confidence interval), was 1.9 (1.2; 3.0) years in previous androgen users. The mean (SD) age of all participants was 33 (8) years.Testosterone secretion after hCG injection was lower in previous users than nonusers: group 1 difference, -6.4 (-11.3; -1.5) nmol/L, (P = .031); group 2 difference, -14.2 (-19.5; -8.8) nmol/L, (P < .001). LH secretion did not differ between the groups.Multivariate linear regressions using erectile function as a dependent variable revealed that higher testosterone secretion during the hCG test (P = .046) was independently associated with better erectile function, whereas baseline serum testosterone (P = .780) and estradiol (P = .405) were not.</p><p><strong>Conclusion: </strong>Previous illicit androgen users exhibited decreased Leydig cell capacity 2 years after androgen cessation, which potentially influences erectile function.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e3709-e3718"},"PeriodicalIF":5.1000,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users.\",\"authors\":\"Yeliz Bulut, Niels Brandt-Jacobsen, Rasmus Madsen, Mario Thevis, Jan Frystyk, Jakob Albrethsen, Niels Jørgensen, Anders Juul, Caroline Kistorp, Jon Jarløv Rasmussen\",\"doi\":\"10.1210/clinem/dgaf157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>A few studies have explored the impairment of pituitary gonadotroph and Leydig cell function in men who recently ceased illicit androgen use, as assessed by stimulation tests. However, the capacity of the pituitary-testis axis in previous users who discontinued androgen use years ago remains unclear. This study evaluated the pituitary-testis-axis capacity in previous illicit androgen users and nonusers.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of recreational strength training men with (n = 30) and without (n = 26) a history of illicit androgen use. Previous users were subdivided into 2 subgroups based on detectable (group 1, n = 17) and undetectable (group 2, n = 13) performance-enhancing drugs in the urine.We performed gonadotropin-releasing hormone and human chorionic gonadotropin (hCG) stimulation tests. Serum LH was measured with immunoassay, total testosterone, and insulin-like factor 3 with liquid chromatography-tandem mass spectrometry. Sexual function was assessed using the 15-question International Index of Erectile Function questionnaire.</p><p><strong>Results: </strong>Elapsed duration since androgen cessation, geometric mean (95% confidence interval), was 1.9 (1.2; 3.0) years in previous androgen users. The mean (SD) age of all participants was 33 (8) years.Testosterone secretion after hCG injection was lower in previous users than nonusers: group 1 difference, -6.4 (-11.3; -1.5) nmol/L, (P = .031); group 2 difference, -14.2 (-19.5; -8.8) nmol/L, (P < .001). LH secretion did not differ between the groups.Multivariate linear regressions using erectile function as a dependent variable revealed that higher testosterone secretion during the hCG test (P = .046) was independently associated with better erectile function, whereas baseline serum testosterone (P = .780) and estradiol (P = .405) were not.</p><p><strong>Conclusion: </strong>Previous illicit androgen users exhibited decreased Leydig cell capacity 2 years after androgen cessation, which potentially influences erectile function.</p>\",\"PeriodicalId\":50238,\"journal\":{\"name\":\"Journal of Clinical Endocrinology & Metabolism\",\"volume\":\" \",\"pages\":\"e3709-e3718\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Endocrinology & Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1210/clinem/dgaf157\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/clinem/dgaf157","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

背景和目的:一些研究探讨了最近停止非法使用雄激素的男性垂体促性腺激素和间质细胞功能的损害,如刺激试验所评估的那样。然而,多年前停用雄激素的患者的垂体-睾丸轴功能尚不清楚。本研究评估了先前非法雄激素使用者和非使用者的垂体-睾丸轴能力。方法:我们对有(n=30)和无(n=26)非法雄激素使用史的娱乐性力量训练男性进行了横断面研究。根据尿液中可检测到的(第1组,n=17)和不可检测到的(第2组,n=13)提高成绩的药物,将既往用药者再分为两组。我们进行了促性腺激素释放激素和hCG刺激试验。免疫分析法测定血清LH, LC-MS/MS法测定总睾酮和胰岛素样因子3。性功能评估采用IIEF-15问卷。结果:雄激素停止使用后的持续时间,几何平均值(95%CI)为1.9年(1.2年;3.0年)。所有参与者的平均(SD)年龄为33(8)岁。注射hCG后,既往服用者睾酮分泌低于未服用者:第一组差异为-6.4(-11.3;-1.5) nmol/L, (P=0.031);2组差异-14.2(-19.5;结论:先前的非法雄激素使用者在停用雄激素两年后显示出间质细胞容量下降,这可能影响勃起功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users.

Background and objectives: A few studies have explored the impairment of pituitary gonadotroph and Leydig cell function in men who recently ceased illicit androgen use, as assessed by stimulation tests. However, the capacity of the pituitary-testis axis in previous users who discontinued androgen use years ago remains unclear. This study evaluated the pituitary-testis-axis capacity in previous illicit androgen users and nonusers.

Methods: We conducted a cross-sectional study of recreational strength training men with (n = 30) and without (n = 26) a history of illicit androgen use. Previous users were subdivided into 2 subgroups based on detectable (group 1, n = 17) and undetectable (group 2, n = 13) performance-enhancing drugs in the urine.We performed gonadotropin-releasing hormone and human chorionic gonadotropin (hCG) stimulation tests. Serum LH was measured with immunoassay, total testosterone, and insulin-like factor 3 with liquid chromatography-tandem mass spectrometry. Sexual function was assessed using the 15-question International Index of Erectile Function questionnaire.

Results: Elapsed duration since androgen cessation, geometric mean (95% confidence interval), was 1.9 (1.2; 3.0) years in previous androgen users. The mean (SD) age of all participants was 33 (8) years.Testosterone secretion after hCG injection was lower in previous users than nonusers: group 1 difference, -6.4 (-11.3; -1.5) nmol/L, (P = .031); group 2 difference, -14.2 (-19.5; -8.8) nmol/L, (P < .001). LH secretion did not differ between the groups.Multivariate linear regressions using erectile function as a dependent variable revealed that higher testosterone secretion during the hCG test (P = .046) was independently associated with better erectile function, whereas baseline serum testosterone (P = .780) and estradiol (P = .405) were not.

Conclusion: Previous illicit androgen users exhibited decreased Leydig cell capacity 2 years after androgen cessation, which potentially influences erectile function.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Clinical Endocrinology & Metabolism
Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢
CiteScore
11.40
自引率
5.20%
发文量
673
审稿时长
1 months
期刊介绍: The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信