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IF 4.6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in nuclear medicine Pub Date : 2025-03-01 DOI:10.1053/j.semnuclmed.2025.02.009

Fawziah Alorfi MD , Jamshed Bomanji MD, PhD , Linda Bertoletti MD , Francesco Fraioli MD

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引用次数: 0

摘要

肺癌仍然是全球癌症相关死亡的主要原因，其中非小细胞肺癌（NSCLC）占 80%-85% 的病例。准确的成像对于分期、治疗计划和随访至关重要。CT 和 PET/CT 是标准的成像模式，而 PET/MR 则是一种相对较新且前景广阔的无辐射技术，它结合了 MRI 的潜力和 PET 扫描的代谢信息，具有不可否认的优势，包括：对比分辨率高，尤其是在软组织中；通过特定的 MRI 序列（如扩散加权和灌注序列）获得功能信息，反映细胞水平的变化；与 CT 和 PET/CT 相比，在检测常见转移部位（如脑、肝、肾上腺和骨）的转移方面具有更高的灵敏度。这些优势使 PET/MR 成为肺癌综合分期的重要工具。虽然 PET/MR 尚未成为常规临床工具，但成像技术的不断进步、方案优化和大规模研究可能会使 PET/MR 成为肺癌个性化治疗的关键组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PET/MRI in Non-Small Cell Lung Cancer (NSCLC)

Lung cancer remains the leading cause of cancer-related deaths worldwide, with nonsmall cell lung cancer (NSCLC) accounting for 80%-85% of cases. Accurate imaging is critical for staging, treatment planning, and follow-up. While CT and PET/CT are standard imaging modalities, PET/MR is a relatively new and promising radiation free technique combining the potentiality of MRI with the metabolic information of PET scans, allowing undeniable advantages including: superior contrast resolution, particularly in soft tissues; functional information through specific MRI sequences (eg, diffusion-weighted and perfusion sequences), reflecting changes at a cellular level; and more superior sensitivity compared to CT and PET/CT for detecting metastases in common metastatic sites such as the brain, liver, adrenal glands, and bone. These advantages position PET/MR as a valuable tool in comprehensive lung cancer staging. While it is not yet a routine clinical tool, ongoing advancements in imaging technology, protocol optimization, and large-scale studies may establish PET/MR as a key component in the personalized management of lung cancer.

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来源期刊

Seminars in nuclear medicine 医学-核医学

CiteScore

9.80

自引率

6.10%

发文量

审稿时长

14 days

期刊介绍： Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.