Notch信号在癌症中的作用：机制和潜在治疗。

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1542967

Chen Chen, Yan Du, Rongzu Nie, Shuangshuang Wang, Hang Wang, Peifeng Li

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引用次数: 0

摘要

Notch信号通路是一个进化上保守的细胞间信号级联，调节许多细胞过程，包括细胞发育、增殖、凋亡和基因组稳定性。Notch信号通路广泛存在于人体中，影响肿瘤的发生和发展，是肿瘤发生和发展中最重要的信号通路之一，影响肿瘤细胞的各种受体和细胞功能。Notch的异常表达或突变与多种恶性肿瘤的发生和发展有关。本文综述了Notch信号通路在肺癌、肝癌和结直肠癌中的作用机制，并探讨了未来通过调控Notch信号通路治疗癌症的策略和方向。

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Notch signaling in cancers: mechanism and potential therapy.

The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive in the human body, affecting tumorigenesis and progression, which is one of the most significant signaling pathways in this regard, influencing various receptors and cellular functions of tumor cells. Aberrant expression or mutation of Notch has been linked to the onset and progression of a variety of malignant tumors. In this review, we discussed the mechanism of Notch signaling in lung, liver and colorectal cancer and explored future strategies and directions for cancer treatment by modifying the Notch signaling pathway.

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.