癌症免疫疗法:导航免疫景观。

IF 2.3 4区 医学 Q3 ONCOLOGY
Rakesh Kumar, Joseph Finian Maleme, Shubham Kumar, Kalvatala Sudhakar, Darshan R Telange, Oshin Maiti, Pratibha Sahoo, Alaa A A Aljabali, Vijay Mishra, Yachana Mishra
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引用次数: 0

摘要

生物技术为利用生物系统的癌症疗法的发展铺平了道路。癌症免疫治疗(CI)是一种关键和快速发展的治疗方式,与手术干预,细胞毒性化疗,放射治疗和靶向治疗。因此,这是癌症管理的第五个基石。生物技术药物是与传统化学治疗并列的对抗肿瘤条件的优越方式。考虑到经验证据,可以假设生物技术在靶向与癌症相关的恶性细胞方面表现出更高的精确度,从而与传统化疗方法相比最大限度地减少附带损害。此外,这种方法利用免疫系统的固有能力来阻止癌症复发,从而促进更积极的治疗干预,而不仅仅是有害的补救措施。新的癌症免疫治疗药物,以及简单的方法,能够定量评估能够修饰T细胞介导的肿瘤抗原特异性免疫反应的化合物的有效性,在评估过程中发挥关键作用。这凸显了免疫疗法、单克隆抗体和一系列生物技术产品在对抗癌症的无情战斗中的巨大前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer Immunotherapies: Navigating the Immune Landscape.

Biotechnology has paved the way for the development of cancer therapeutics that harness biological systems. Cancer immunotherapy (CI) is a pivotal and swiftly progressing therapeutic modality, alongside surgical intervention, cytotoxic chemo-therapy, radiation therapy, and targeted therapy. Therefore, this is the fifth cornerstone of cancer management. Biotechnological pharmaceuticals are superior modalities for combat-ing neoplastic conditions when juxtaposed with conventional chemical therapeutics. Consid-ering empirical evidence, it can be posited that biotechnology exhibits a heightened level of precision in targeting malignant cells associated with cancer, thereby minimizing collateral damage compared to conventional chemotherapeutic approaches. Furthermore, this ap-proach harnesses the inherent capabilities of the immune system to impede cancer recur-rence, thereby facilitating a more proactive therapeutic intervention, as opposed to a mere deleterious remedy. Novel cancer immunotherapeutic medications, along with uncomplicat-ed methodologies that enable the quantitative evaluation of the effectiveness of compounds capable of modifying T cell-mediated, tumor antigen-specific immune responses, play a pivotal role in the assessment process. This highlights the considerable promise of immuno-therapies, monoclonal antibodies, and an array of biotechnological products in a relentless battle against cancer.

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来源期刊
Current cancer drug targets
Current cancer drug targets 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
105
审稿时长
1 months
期刊介绍: Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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