Maria Giulia Caponcello, Paula Olivares Navarro, Cecilia Bonazzetti, Caterina Campoli, Alessia Savoldi, Elisa Gentilotti, Antonella d'Arminio Monforte, Sergio Lo Caputo, Lucía Otero-Varela, Isabel Castrejón, Evelina Tacconelli, Jesús Rodríguez-Baño, Zaira R Palacios-Baena, Dolores Mendoza Mendoza, Virginia Moreira Navarrete, Alessandro Tomelleri, Lotta Ljung, Teresa Martins Rocha, Pedro Palma, Zaira R Palacios-Baena, Elena Salamanca-Rivera, María Paniagua-García, Angelo Fassio, Riccardo Bixio, Enrico Tombetti, Fabrizio Conti
{"title":"ORCHESTRA Delphi consensus: diagnostic and therapeutic management of SARS-CoV-2 infection in patients with rheumatological diseases.","authors":"Maria Giulia Caponcello, Paula Olivares Navarro, Cecilia Bonazzetti, Caterina Campoli, Alessia Savoldi, Elisa Gentilotti, Antonella d'Arminio Monforte, Sergio Lo Caputo, Lucía Otero-Varela, Isabel Castrejón, Evelina Tacconelli, Jesús Rodríguez-Baño, Zaira R Palacios-Baena, Dolores Mendoza Mendoza, Virginia Moreira Navarrete, Alessandro Tomelleri, Lotta Ljung, Teresa Martins Rocha, Pedro Palma, Zaira R Palacios-Baena, Elena Salamanca-Rivera, María Paniagua-García, Angelo Fassio, Riccardo Bixio, Enrico Tombetti, Fabrizio Conti","doi":"10.1016/j.cmi.2025.02.030","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The clinical management of COVID-19 in immunocompromised patients remains a challenge. This work aimed to develop a consensus to establish recommendations for the clinical, diagnostic, and therapeutic management of patients with rheumatic diseases and COVID-19.</p><p><strong>Methods: </strong>A panel of 14 international experts was selected, and Delphi methodology was used for the consensus, after a systematic literature review. Twenty-four questions were formulated and presented to the panel. The experts voted using a 6-point Likert scale (1) 'Strongly disagree' (SD); (2) 'Disagree' (D); (3) 'Somewhat disagree' (SWD); (4) 'Somewhat agree' (SWA); (5) 'Agree' (A); (6) 'Strongly agree' (SA). To establish consensus, simple or cumulative agreement ≥80% was required over a maximum of three rounds. Cumulative agreement was defined as the sum of response percentages on items 1-2 (SD + D); 2-3 (D + SWD); 4-5 (SWA + A); or 5-6 (A + SA), distinguishing a strong degree of agreement (A + SA) or disagreement (SD + D) from a moderate degree of agreement (SWA + A) or disagreement (D + SWD).</p><p><strong>Results: </strong>After the three rounds, consensus was reached on 23 of the 24 questions and 10 recommendations were made.</p><p><strong>Discussion: </strong>The Delphi methodology allowed consensus on recommendations in areas with insufficient scientific evidence, which can be considered for decision-making in the management of patients with rheumatological diseases while awaiting better evidence.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Microbiology and Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cmi.2025.02.030","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of SARS-CoV-2 infection in patients with rheumatological diseases.
Objectives: The clinical management of COVID-19 in immunocompromised patients remains a challenge. This work aimed to develop a consensus to establish recommendations for the clinical, diagnostic, and therapeutic management of patients with rheumatic diseases and COVID-19.
Methods: A panel of 14 international experts was selected, and Delphi methodology was used for the consensus, after a systematic literature review. Twenty-four questions were formulated and presented to the panel. The experts voted using a 6-point Likert scale (1) 'Strongly disagree' (SD); (2) 'Disagree' (D); (3) 'Somewhat disagree' (SWD); (4) 'Somewhat agree' (SWA); (5) 'Agree' (A); (6) 'Strongly agree' (SA). To establish consensus, simple or cumulative agreement ≥80% was required over a maximum of three rounds. Cumulative agreement was defined as the sum of response percentages on items 1-2 (SD + D); 2-3 (D + SWD); 4-5 (SWA + A); or 5-6 (A + SA), distinguishing a strong degree of agreement (A + SA) or disagreement (SD + D) from a moderate degree of agreement (SWA + A) or disagreement (D + SWD).
Results: After the three rounds, consensus was reached on 23 of the 24 questions and 10 recommendations were made.
Discussion: The Delphi methodology allowed consensus on recommendations in areas with insufficient scientific evidence, which can be considered for decision-making in the management of patients with rheumatological diseases while awaiting better evidence.
期刊介绍：
Clinical Microbiology and Infection (CMI) is a monthly journal published by the European Society of Clinical Microbiology and Infectious Diseases. It focuses on peer-reviewed papers covering basic and applied research in microbiology, infectious diseases, virology, parasitology, immunology, and epidemiology as they relate to therapy and diagnostics.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
