UBE2T在人类癌症中的生物学功能和治疗潜力。

IF 2.3 4区 医学 Q3 ONCOLOGY
Keshen Wang, Qichen He, Xiangyan Jiang, Yong Ma, Tao Wang, Huinian Zhou, Zeyuan Yu, Zuoyi Jiao
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引用次数: 0

摘要

泛素-蛋白酶体系统是真核细胞中控制蛋白质稳定性和细胞内信号传导的基本调控机制。该系统依赖于包括激活酶、偶联酶和连接酶在内的酶活动的协调级联来组装不同的泛素信号。这些信号随后被去泛素酶和泛素结合蛋白编辑、移除或解释。虽然E3连接酶传统上被认为是泛素化过程中底物特异性的主要决定因素,但最近的研究表明,E2酶的失调也可能导致显著的病理结果,包括染色质不稳定、免疫失调、代谢功能障碍和癌症风险升高。因此,E2酶已成为治疗各种疾病的有希望的治疗靶点。本文综述了泛素偶联酶E2T (UBE2T)在癌症发生、进展和治疗耐药中的作用和机制,强调了其作为癌症治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological Functions and Therapeutic Potential of UBE2T in Human Cancer.

The ubiquitin-proteasome system is a fundamental regulatory mechanism that governs protein stability and intracellular signaling in eukaryotic cells. This system relies on a coordinated cascade of enzymatic activities involving activating enzymes, conjugating enzymes, and ligases to assemble distinct ubiquitin signals. These signals are subsequently edited, removed, or interpreted by deubiquitinases and ubiquitin-binding proteins. While E3 ligases have traditionally been recognized as the primary determinants of substrate specificity in the ubiquitination process, recent studies have revealed that the dysregulation of E2 enzymes can also lead to significant pathological outcomes, including chromatin instability, immune dysregulation, metabolic dysfunction, and an elevated risk of cancer. Consequently, E2 enzymes have emerged as promising therapeutic targets for the treatment of various dis-eases. This review provides a comprehensive examination of the roles and mechanisms of the ubiquitin-conjugating enzyme E2T (UBE2T) in cancer initiation, progression, and therapy resistance, highlighting its potential as a compelling target for cancer therapeutics.

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来源期刊
Current cancer drug targets
Current cancer drug targets 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
105
审稿时长
1 months
期刊介绍: Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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