壳聚糖/纤维素/单宁酸多功能快速止血海绵的生物相容性研究

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-04-14 DOI:10.1021/acs.biomac.4c01840

Yuanyuan Ma , Guowei Da , Lei He , Jinda Peng , Qian Han , Yongze Liu , Juqing Cui , Jun Zhang , Xiaofeng Ma

{"title":"壳聚糖/纤维素/单宁酸多功能快速止血海绵的生物相容性研究","authors":"Yuanyuan Ma , Guowei Da , Lei He , Jinda Peng , Qian Han , Yongze Liu , Juqing Cui , Jun Zhang , Xiaofeng Ma","doi":"10.1021/acs.biomac.4c01840","DOIUrl":null,"url":null,"abstract":"<div><div>Hemostatic materials should have efficient and rapid hemostasis, good biocompatibility, and nontoxicity. However, common hemostatic sponges often fail due to their weak mechanical strength, low biocompatibility, and slow hemostasis. Herein, we have developed novel and multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite sponges by a freeze-drying method without adding any chemical cross-linking agents. The water absorption rate of the biocomposite sponge is as high as 4404%, and the blood absorption rate is as high as 5460%. <em>In vitro</em> coagulation tests have shown that the coagulation ability of CS/OMCC/TA biocomposite sponges is significantly better than that of commercial hemostasis materials. DPPH radical scavenging test and antibacterial experiments demonstrated excellent antioxidant properties and inhibitory effects on Staphylococcus aureus and Escherichia coli. Animal experiments showed that CS/OMCC/TA biocomposite sponges could rapidly hemostasize within 185 s and the blood loss was as low as 107 mg. These findings provide biocompatible and rapid hemostatic materials for the daily emergency trauma treatment and surgical hemostasis.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (164KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 4","pages":"Pages 2467-2478"},"PeriodicalIF":5.4000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multifunctional Chitosan/Cellulose/Tannic Acid Biocomposite Sponge with Excellent Biocompatibility for Rapid Hemostasis\",\"authors\":\"Yuanyuan Ma , Guowei Da , Lei He , Jinda Peng , Qian Han , Yongze Liu , Juqing Cui , Jun Zhang , Xiaofeng Ma\",\"doi\":\"10.1021/acs.biomac.4c01840\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Hemostatic materials should have efficient and rapid hemostasis, good biocompatibility, and nontoxicity. However, common hemostatic sponges often fail due to their weak mechanical strength, low biocompatibility, and slow hemostasis. Herein, we have developed novel and multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite sponges by a freeze-drying method without adding any chemical cross-linking agents. The water absorption rate of the biocomposite sponge is as high as 4404%, and the blood absorption rate is as high as 5460%. <em>In vitro</em> coagulation tests have shown that the coagulation ability of CS/OMCC/TA biocomposite sponges is significantly better than that of commercial hemostasis materials. DPPH radical scavenging test and antibacterial experiments demonstrated excellent antioxidant properties and inhibitory effects on Staphylococcus aureus and Escherichia coli. Animal experiments showed that CS/OMCC/TA biocomposite sponges could rapidly hemostasize within 185 s and the blood loss was as low as 107 mg. These findings provide biocompatible and rapid hemostatic materials for the daily emergency trauma treatment and surgical hemostasis.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (164KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>\",\"PeriodicalId\":30,\"journal\":{\"name\":\"Biomacromolecules\",\"volume\":\"26 4\",\"pages\":\"Pages 2467-2478\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomacromolecules\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S152577972500114X\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S152577972500114X","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

止血材料应具有有效、快速止血、生物相容性好、无毒等特点。然而，普通止血海绵由于机械强度弱、生物相容性低、止血缓慢等原因，常常失效。本研究在不添加任何化学交联剂的情况下，采用冷冻干燥方法制备了新型多功能壳聚糖/纤维素/单宁酸（CS/OMCC/TA）生物复合海绵。生物复合海绵吸水率高达4404%，血液吸收率高达5460%。体外凝血试验表明，CS/OMCC/TA生物复合海绵的凝血能力明显优于市售止血材料。DPPH自由基清除实验和抗菌实验均显示出良好的抗氧化性能和对金黄色葡萄球菌和大肠杆菌的抑制作用。动物实验表明，CS/OMCC/TA复合海绵可在185 s内快速止血，出血量低至107 mg。这些发现为日常急诊创伤治疗和外科止血提供了生物相容性和快速止血材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Multifunctional Chitosan/Cellulose/Tannic Acid Biocomposite Sponge with Excellent Biocompatibility for Rapid Hemostasis

Hemostatic materials should have efficient and rapid hemostasis, good biocompatibility, and nontoxicity. However, common hemostatic sponges often fail due to their weak mechanical strength, low biocompatibility, and slow hemostasis. Herein, we have developed novel and multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite sponges by a freeze-drying method without adding any chemical cross-linking agents. The water absorption rate of the biocomposite sponge is as high as 4404%, and the blood absorption rate is as high as 5460%. In vitro coagulation tests have shown that the coagulation ability of CS/OMCC/TA biocomposite sponges is significantly better than that of commercial hemostasis materials. DPPH radical scavenging test and antibacterial experiments demonstrated excellent antioxidant properties and inhibitory effects on Staphylococcus aureus and Escherichia coli. Animal experiments showed that CS/OMCC/TA biocomposite sponges could rapidly hemostasize within 185 s and the blood loss was as low as 107 mg. These findings provide biocompatible and rapid hemostatic materials for the daily emergency trauma treatment and surgical hemostasis.

Download: Download high-res image (164KB)
Download: Download full-size image

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.