Joao Escalda, Brigite Pedro, Jose Novo Matos, Antonia Mavropoulou, Christopher Linney, Joao Neves, Joanna Dukes-McEwan, Anna R. Gelzer
{"title":"房颤犬的日心率变异性","authors":"Joao Escalda, Brigite Pedro, Jose Novo Matos, Antonia Mavropoulou, Christopher Linney, Joao Neves, Joanna Dukes-McEwan, Anna R. Gelzer","doi":"10.1111/jvim.70051","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Daily variability of heart rate in 24-h Holter recordings in dogs with atrial fibrillation (AF) receiving antiarrhythmic drugs (AAD) is unknown and could influence medical decisions.</p>\n </section>\n \n <section>\n \n <h3> Hypothesis/Objectives</h3>\n \n <p>Dogs with AF, Holter-derived mean heart rate (meanHRHolter) over 24 h is not significantly different from a subsequent, consecutive 24-h period.</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>Twenty-five dogs with AF.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Prospective, descriptive, multicenter study. MeanHRHolter rate and ventricular arrhythmias (VAs) were prospectively analyzed after starting AAD. Clinically relevant difference (defined as ≥ 10 bpm in the meanHRHolter), success of rate control (defined as meanHRHolter ≤ 125 bpm). A Bland–Altman analysis and intra-class correlation coefficient (ICC) were calculated to compare two consecutive 24-h Holter recordings. VAs percentage difference [(maximum daily value-minimum daily value)/maximum daily value × 100] and grading variability between recordings were also investigated.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Small BIAS with ICC 0.98 (95% confidence interval [CI] 0.95–0.99) on meanHRHolter with no statistical difference between two consecutive 24-h Holter recordings (95% CI [−2.84–2.92], degree of freedom 24, <i>p</i> = 0.98). Only 2/25 dogs (8%; 95% CI [2%–25%]) had clinically significant variation, while 1/25 (4%; 95% CI [0%–20%]) dogs showed different classifications in the success of rate control between the consecutive recordings. The VAs percentage difference was 52%, with 7/25 (28%; 95% CI [14%–47%]) dogs showing a VAs grading difference of ≥ 2.</p>\n </section>\n \n <section>\n \n <h3> Conclusion and Clinical Importance</h3>\n \n <p>The daily heart rate variability in dogs with AF receiving AAD is low, suggesting that a single 24-h Holter recording is adequate to assess rate control. Daily variability might be an important consideration when assessing VAs in dogs with concomitant AF.</p>\n </section>\n </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70051","citationCount":"0","resultStr":"{\"title\":\"Daily Heart Rate Variability in Dogs With Atrial Fibrillation\",\"authors\":\"Joao Escalda, Brigite Pedro, Jose Novo Matos, Antonia Mavropoulou, Christopher Linney, Joao Neves, Joanna Dukes-McEwan, Anna R. Gelzer\",\"doi\":\"10.1111/jvim.70051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Daily variability of heart rate in 24-h Holter recordings in dogs with atrial fibrillation (AF) receiving antiarrhythmic drugs (AAD) is unknown and could influence medical decisions.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Hypothesis/Objectives</h3>\\n \\n <p>Dogs with AF, Holter-derived mean heart rate (meanHRHolter) over 24 h is not significantly different from a subsequent, consecutive 24-h period.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Animals</h3>\\n \\n <p>Twenty-five dogs with AF.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Prospective, descriptive, multicenter study. MeanHRHolter rate and ventricular arrhythmias (VAs) were prospectively analyzed after starting AAD. Clinically relevant difference (defined as ≥ 10 bpm in the meanHRHolter), success of rate control (defined as meanHRHolter ≤ 125 bpm). A Bland–Altman analysis and intra-class correlation coefficient (ICC) were calculated to compare two consecutive 24-h Holter recordings. VAs percentage difference [(maximum daily value-minimum daily value)/maximum daily value × 100] and grading variability between recordings were also investigated.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Small BIAS with ICC 0.98 (95% confidence interval [CI] 0.95–0.99) on meanHRHolter with no statistical difference between two consecutive 24-h Holter recordings (95% CI [−2.84–2.92], degree of freedom 24, <i>p</i> = 0.98). Only 2/25 dogs (8%; 95% CI [2%–25%]) had clinically significant variation, while 1/25 (4%; 95% CI [0%–20%]) dogs showed different classifications in the success of rate control between the consecutive recordings. The VAs percentage difference was 52%, with 7/25 (28%; 95% CI [14%–47%]) dogs showing a VAs grading difference of ≥ 2.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion and Clinical Importance</h3>\\n \\n <p>The daily heart rate variability in dogs with AF receiving AAD is low, suggesting that a single 24-h Holter recording is adequate to assess rate control. 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Daily Heart Rate Variability in Dogs With Atrial Fibrillation
Background
Daily variability of heart rate in 24-h Holter recordings in dogs with atrial fibrillation (AF) receiving antiarrhythmic drugs (AAD) is unknown and could influence medical decisions.
Hypothesis/Objectives
Dogs with AF, Holter-derived mean heart rate (meanHRHolter) over 24 h is not significantly different from a subsequent, consecutive 24-h period.
Animals
Twenty-five dogs with AF.
Methods
Prospective, descriptive, multicenter study. MeanHRHolter rate and ventricular arrhythmias (VAs) were prospectively analyzed after starting AAD. Clinically relevant difference (defined as ≥ 10 bpm in the meanHRHolter), success of rate control (defined as meanHRHolter ≤ 125 bpm). A Bland–Altman analysis and intra-class correlation coefficient (ICC) were calculated to compare two consecutive 24-h Holter recordings. VAs percentage difference [(maximum daily value-minimum daily value)/maximum daily value × 100] and grading variability between recordings were also investigated.
Results
Small BIAS with ICC 0.98 (95% confidence interval [CI] 0.95–0.99) on meanHRHolter with no statistical difference between two consecutive 24-h Holter recordings (95% CI [−2.84–2.92], degree of freedom 24, p = 0.98). Only 2/25 dogs (8%; 95% CI [2%–25%]) had clinically significant variation, while 1/25 (4%; 95% CI [0%–20%]) dogs showed different classifications in the success of rate control between the consecutive recordings. The VAs percentage difference was 52%, with 7/25 (28%; 95% CI [14%–47%]) dogs showing a VAs grading difference of ≥ 2.
Conclusion and Clinical Importance
The daily heart rate variability in dogs with AF receiving AAD is low, suggesting that a single 24-h Holter recording is adequate to assess rate control. Daily variability might be an important consideration when assessing VAs in dogs with concomitant AF.
期刊介绍:
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.