对连续流加热机械化学技术的影响：一种改进的溶剂合成方法

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2024-10-22 DOI:10.1007/s41981-024-00339-8

Rémi Nguyen, Samy Haloumi, Irene Malpartida, Christophe Len

{"title":"对连续流加热机械化学技术的影响：一种改进的溶剂合成方法","authors":"Rémi Nguyen, Samy Haloumi, Irene Malpartida, Christophe Len","doi":"10.1007/s41981-024-00339-8","DOIUrl":null,"url":null,"abstract":"<div><p>Impact in Continuous flow Heated Mechanochemistry (ICHEM) was used for the production of solketal at 60 °C using glycerol and acetone in the presence of homogeneous FeCl<sub>3</sub>.6H<sub>2</sub>O (1 mol%). In our optimized conditions, the target compound was obtained in 96% yield (conversion of 97% and selectivity of 99%) with a productivity of 276 g day<sup>–1</sup> with a 80 mL continuous flow reactor. This new technology combines beads mechanochemistry and continuous flow and offers: (i) a better mixing of the two unsoluble parts (glycerol and acetone) by reducing the viscosity of the feed stream and (ii) an alternative of the single-screw and double-screw extruders which are unefficient with a liquid reaction media.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"15 1","pages":"1 - 9"},"PeriodicalIF":2.0000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact in continuous flow heated mechanochemical technology: An improved solketal synthesis\",\"authors\":\"Rémi Nguyen, Samy Haloumi, Irene Malpartida, Christophe Len\",\"doi\":\"10.1007/s41981-024-00339-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Impact in Continuous flow Heated Mechanochemistry (ICHEM) was used for the production of solketal at 60 °C using glycerol and acetone in the presence of homogeneous FeCl<sub>3</sub>.6H<sub>2</sub>O (1 mol%). In our optimized conditions, the target compound was obtained in 96% yield (conversion of 97% and selectivity of 99%) with a productivity of 276 g day<sup>–1</sup> with a 80 mL continuous flow reactor. This new technology combines beads mechanochemistry and continuous flow and offers: (i) a better mixing of the two unsoluble parts (glycerol and acetone) by reducing the viscosity of the feed stream and (ii) an alternative of the single-screw and double-screw extruders which are unefficient with a liquid reaction media.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":630,\"journal\":{\"name\":\"Journal of Flow Chemistry\",\"volume\":\"15 1\",\"pages\":\"1 - 9\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Flow Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s41981-024-00339-8\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Flow Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s41981-024-00339-8","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

采用连续流动冲击加热机械化学（ICHEM）方法，在60℃条件下，以均匀的FeCl3.6H2O （1mol %）存在下，以甘油和丙酮为原料制备索酮。在优化条件下，在80 mL连续流反应器中，目标化合物的收率为96%（转化率为97%，选择性为99%），产率为276 g day-1。这项新技术结合了微珠机械化学和连续流动，提供了：(i)通过降低进料流的粘度，更好地混合了两种不溶性成分（甘油和丙酮）；（ii）替代了单螺杆和双螺杆挤出机，这两种挤出机在液体反应介质中效率不高。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Impact in continuous flow heated mechanochemical technology: An improved solketal synthesis

查看原文本刊更多论文

Impact in continuous flow heated mechanochemical technology: An improved solketal synthesis

Impact in Continuous flow Heated Mechanochemistry (ICHEM) was used for the production of solketal at 60 °C using glycerol and acetone in the presence of homogeneous FeCl₃.6H₂O (1 mol%). In our optimized conditions, the target compound was obtained in 96% yield (conversion of 97% and selectivity of 99%) with a productivity of 276 g day^–1 with a 80 mL continuous flow reactor. This new technology combines beads mechanochemistry and continuous flow and offers: (i) a better mixing of the two unsoluble parts (glycerol and acetone) by reducing the viscosity of the feed stream and (ii) an alternative of the single-screw and double-screw extruders which are unefficient with a liquid reaction media.

Graphical abstract

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.