Adam W Autry, Yaewon Kim, Duy Dang, Hsin-Yu Chen, James B Slater, Robert A Bok, Duan Xu, Janine M Lupo, Jeremy W Gordon, Peder E Z Larson, Daniel B Vigneron, Yan Li, Susan M Chang
{"title":"超极化13C代谢探针在胶质瘤成像中的临床应用","authors":"Adam W Autry, Yaewon Kim, Duy Dang, Hsin-Yu Chen, James B Slater, Robert A Bok, Duan Xu, Janine M Lupo, Jeremy W Gordon, Peder E Z Larson, Daniel B Vigneron, Yan Li, Susan M Chang","doi":"10.3174/ajnr.A8726","DOIUrl":null,"url":null,"abstract":"<p><p>Hyperpolarized carbon-13 (HP-<sup>13</sup>C) MRI enables the real-time measurement of dynamic metabolism by utilizing molecular probes whose magnetization has been transiently enhanced via dynamic nuclear polarization of <sup>13</sup>C labels. Based on preclinical and clinical investigations demonstrating Warburg-related metabolic dysfunction and tricarboxylic acid (TCA)-cycle alterations in gliomas, HP-<sup>13</sup>C techniques appear very promising for overcoming conventional challenges to evaluating tumor burden and extent, early therapeutic response, and progression among patients noninvasively. This article surveys the multifaceted translational development of HP-<sup>13</sup>C MRI in the context of glioma imaging, while emphasizing innovation concerning the pharmacy production of hyperpolarized (HP) probes-[1-<sup>13</sup>C]/[2-<sup>13</sup>C]-pyruvate and [1-<sup>13</sup>C,5-<sup>12</sup>C]-α-ketoglutarate-that serve as nonradioactive metabolic contrast agents. Borrowing from practical experience, we present specific probe indications for isocitrate dehydrogenase (IDH)-wild-type glioblastomas and IDH-mutant gliomas together with example data to show the targeted, pathway-dependent function of these agents and their utility. Additional information pertaining to HP-<sup>13</sup>C hardware, acquisition, and postprocessing techniques provides an overview of the imaging methodology as it is currently performed at a leading institution. Considering the developing markers for progressive disease in glioblastomas and rapidly advancing capability, this unique imaging technology appears poised for translational impact following further evaluation.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"1754-1764"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453463/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical Translation of Hyperpolarized <sup>13</sup>C Metabolic Probes for Glioma Imaging.\",\"authors\":\"Adam W Autry, Yaewon Kim, Duy Dang, Hsin-Yu Chen, James B Slater, Robert A Bok, Duan Xu, Janine M Lupo, Jeremy W Gordon, Peder E Z Larson, Daniel B Vigneron, Yan Li, Susan M Chang\",\"doi\":\"10.3174/ajnr.A8726\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hyperpolarized carbon-13 (HP-<sup>13</sup>C) MRI enables the real-time measurement of dynamic metabolism by utilizing molecular probes whose magnetization has been transiently enhanced via dynamic nuclear polarization of <sup>13</sup>C labels. Based on preclinical and clinical investigations demonstrating Warburg-related metabolic dysfunction and tricarboxylic acid (TCA)-cycle alterations in gliomas, HP-<sup>13</sup>C techniques appear very promising for overcoming conventional challenges to evaluating tumor burden and extent, early therapeutic response, and progression among patients noninvasively. This article surveys the multifaceted translational development of HP-<sup>13</sup>C MRI in the context of glioma imaging, while emphasizing innovation concerning the pharmacy production of hyperpolarized (HP) probes-[1-<sup>13</sup>C]/[2-<sup>13</sup>C]-pyruvate and [1-<sup>13</sup>C,5-<sup>12</sup>C]-α-ketoglutarate-that serve as nonradioactive metabolic contrast agents. Borrowing from practical experience, we present specific probe indications for isocitrate dehydrogenase (IDH)-wild-type glioblastomas and IDH-mutant gliomas together with example data to show the targeted, pathway-dependent function of these agents and their utility. Additional information pertaining to HP-<sup>13</sup>C hardware, acquisition, and postprocessing techniques provides an overview of the imaging methodology as it is currently performed at a leading institution. Considering the developing markers for progressive disease in glioblastomas and rapidly advancing capability, this unique imaging technology appears poised for translational impact following further evaluation.</p>\",\"PeriodicalId\":93863,\"journal\":{\"name\":\"AJNR. 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Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging.
Hyperpolarized carbon-13 (HP-13C) MRI enables the real-time measurement of dynamic metabolism by utilizing molecular probes whose magnetization has been transiently enhanced via dynamic nuclear polarization of 13C labels. Based on preclinical and clinical investigations demonstrating Warburg-related metabolic dysfunction and tricarboxylic acid (TCA)-cycle alterations in gliomas, HP-13C techniques appear very promising for overcoming conventional challenges to evaluating tumor burden and extent, early therapeutic response, and progression among patients noninvasively. This article surveys the multifaceted translational development of HP-13C MRI in the context of glioma imaging, while emphasizing innovation concerning the pharmacy production of hyperpolarized (HP) probes-[1-13C]/[2-13C]-pyruvate and [1-13C,5-12C]-α-ketoglutarate-that serve as nonradioactive metabolic contrast agents. Borrowing from practical experience, we present specific probe indications for isocitrate dehydrogenase (IDH)-wild-type glioblastomas and IDH-mutant gliomas together with example data to show the targeted, pathway-dependent function of these agents and their utility. Additional information pertaining to HP-13C hardware, acquisition, and postprocessing techniques provides an overview of the imaging methodology as it is currently performed at a leading institution. Considering the developing markers for progressive disease in glioblastomas and rapidly advancing capability, this unique imaging technology appears poised for translational impact following further evaluation.