Pharmaceutical Manufacturing with Additive Technology: A Key Driver of Industry 4.0 Integration.

Additive Manufacturing (AM) has emerged as a transformative force in the pharmaceutical industry, establishing itself as a cornerstone of Industry 4.0. This review explores the capability of 3D printing (3DP) technologies that facilitate the creation of individualized dosage forms, precise drug release control, and customized drug delivery systems. These innovations have significantly improved treatment outcomes and efficiency. The study identifies key challenges hindering the widespread adoption of AM in pharmaceuticals, including issues related to material selection, regulatory compliance, and process efficiency. By analyzing the interrelationship between AM and the fundamental pillars of Industry 4.0, we demonstrate how AM can optimize manufacturing costs, reduce production time, and minimize waste. The review also presents a strategic roadmap for future research, emphasizing the need for interdisciplinary collaboration to overcome regulatory barriers, develop medical-grade materials, and optimize manufacturing processes through advanced computational models and machine learning. This approach aims to accelerate the integration of AM into pharmaceutical manufacturing, ultimately enhancing personalized patient care and therapeutic effectiveness.