{"title":"Vitreoscilla 血红蛋白基因在不同生物体中的表达：提高各种生物过程效率的新方法。","authors":"Mahsa Arkani, Valiollah Babaeipour, Reza Mohammadi, Aliasghar Deldar","doi":"10.1080/10826068.2025.2472961","DOIUrl":null,"url":null,"abstract":"<p><p><i>Vitreoscilla</i> hemoglobin (VHb), a 15,775 Da oxygen-binding protein, enhances intracellular oxygen transfer, improves the efficiency of oxygen use, and promotes organism growth and the desired metabolite production. Researchers have investigated VHb gene expression for two decades to enhance aerobic biological processes in diverse organisms. This review examines the protein structure, biochemical characteristics, genetic structure, cellular mechanisms of activity, and protein engineering of VHb. It then assesses the impact of VHb expression on the performance improvement of bacteria, fungi, plants, and mammalian cells in various biological processes. Finally, the article specifically discusses the VHb gene expression strategies in <i>Streptomyces</i>.</p>","PeriodicalId":20401,"journal":{"name":"Preparative Biochemistry & Biotechnology","volume":" ","pages":"1-18"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression of <i>Vitreoscilla</i> hemoglobin gene in different organisms: a new approach to increase the efficiency of various biological processes.\",\"authors\":\"Mahsa Arkani, Valiollah Babaeipour, Reza Mohammadi, Aliasghar Deldar\",\"doi\":\"10.1080/10826068.2025.2472961\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Vitreoscilla</i> hemoglobin (VHb), a 15,775 Da oxygen-binding protein, enhances intracellular oxygen transfer, improves the efficiency of oxygen use, and promotes organism growth and the desired metabolite production. Researchers have investigated VHb gene expression for two decades to enhance aerobic biological processes in diverse organisms. This review examines the protein structure, biochemical characteristics, genetic structure, cellular mechanisms of activity, and protein engineering of VHb. It then assesses the impact of VHb expression on the performance improvement of bacteria, fungi, plants, and mammalian cells in various biological processes. Finally, the article specifically discusses the VHb gene expression strategies in <i>Streptomyces</i>.</p>\",\"PeriodicalId\":20401,\"journal\":{\"name\":\"Preparative Biochemistry & Biotechnology\",\"volume\":\" \",\"pages\":\"1-18\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Preparative Biochemistry & Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1080/10826068.2025.2472961\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Preparative Biochemistry & Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10826068.2025.2472961","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Expression of Vitreoscilla hemoglobin gene in different organisms: a new approach to increase the efficiency of various biological processes.
Vitreoscilla hemoglobin (VHb), a 15,775 Da oxygen-binding protein, enhances intracellular oxygen transfer, improves the efficiency of oxygen use, and promotes organism growth and the desired metabolite production. Researchers have investigated VHb gene expression for two decades to enhance aerobic biological processes in diverse organisms. This review examines the protein structure, biochemical characteristics, genetic structure, cellular mechanisms of activity, and protein engineering of VHb. It then assesses the impact of VHb expression on the performance improvement of bacteria, fungi, plants, and mammalian cells in various biological processes. Finally, the article specifically discusses the VHb gene expression strategies in Streptomyces.
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Preparative Biochemistry & Biotechnology is an international forum for rapid dissemination of high quality research results dealing with all aspects of preparative techniques in biochemistry, biotechnology and other life science disciplines.
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