孕妇紧急接种MVA-ZIKV疫苗在致命寨卡病毒感染快速攻毒模型中的效果

IF 6.5 1区 医学 Q1 IMMUNOLOGY
Asisa Volz, Sabrina Clever, Alina Tscherne, Astrid Freudenstein, Sylvia Jany, Jan H Schwarz, Leonard Limpinsel, William G Valiant, Georgia Kalodimou, Gerd Sutter, Joseph J Mattapallil
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引用次数: 0

摘要

2015年寨卡病毒(ZIKV)暴发与感染寨卡病毒孕妇所生儿童的小头畸形和先天性出生缺陷有关。使用高度易感的I型干扰素受体缺陷小鼠模型,我们证明了单次紧急接种非复制MVA-ZIKV疫苗,当早在攻击前2天施用时,完全保护未怀孕和怀孕的小鼠和胎儿免受致命的zikv感染。早期保护与zikv特异性CD8+ T细胞反应的快速出现有关;CD8+ T细胞的耗竭导致CD8+ T细胞在MVA-ZIKV早期保护功效中支持关键作用的保护丧失。中和抗体反应比CD8+ T细胞反应更晚被诱导,这表明它可能在感染的后期发挥作用。我们的研究结果表明,MVA-ZIKV在感染后早期诱导了强效的健忘性细胞免疫,有助于其对ZIKV快速攻击的保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of emergency maternal MVA-ZIKV vaccination in a rapid challenge model of lethal Zika infection.

Zika virus (ZIKV) outbreak of 2015 was associated with microcephaly and congenital birth defects in children born to pregnant women infected with ZIKV. Using the highly susceptible Type I Interferon Receptor-deficient mouse-model, we demonstrate that a single emergency vaccination with a non-replicating MVA-ZIKV vaccine, when administered as early as 2-days before challenge fully protected non-pregnant and pregnant mice and fetuses against lethal ZIKV-infection. Early protection was associated with the rapid emergence of ZIKV-specific CD8+ T cell responses; depletion of CD8+ T cells resulted in the loss of protection supporting a critical role for CD8+ T cells in the early protective efficacy of MVA-ZIKV. Neutralizing antibody responses were induced later than the CD8+ T cell responses, suggesting that it may play a role in later stages of infection. Our results suggest that MVA-ZIKV induces potent anamnestic cellular immunity early after infection, contributing to its protective efficacy against rapid ZIKV challenge.

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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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