中国学龄前自闭症谱系障碍儿童运动发育迟缓及其与核心症状和母亲危险因素的关系:一项多中心调查

IF 4.6 3区 医学 Q1 PEDIATRICS
Dan Long, Ting Yang, Jie Chen, Jie Zhang, Ying Dai, Li Chen, Feiyong Jia, Lijie Wu, Yan Hao, Ling Li, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Tingyu Li
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引用次数: 0

摘要

背景:运动障碍作为自闭症谱系障碍(ASD)的相关症状尚未得到应有的重视。我们旨在调查中国学龄前ASD儿童不同程度的运动发育迟缓及其影响因素,以提高人们对ASD儿童运动发育迟缓的认识。方法:从中国多中心学龄前自闭症项目(CMPAP)中招募1256名2-6岁的ASD儿童。我们通过修订儿童神经心理与行为量表(CNBS-R2016)和Gesell发育量表(GDS)对学龄前ASD儿童神经发育的整体状况进行了调查。采用多变量有序logistic回归模型分析不同程度运动发育迟缓与人口统计学、ASD核心症状、母体危险因素的关系,并采用问卷、儿童自闭症评定量表(CARS)、社会反应量表-第二版(SRS-2)进行评估。结果:学龄前ASD患儿各神经发育领域发育迟缓比例明显失衡。大动作和精细动作发育迟缓的比例分别高达39.6%和68.4%。不同年龄组的ASD患儿均表现出大、细运动发育迟缓。轻、中、重度大、细动作发育迟缓患儿的CARS和SRS-2总分显著高于运动技能发育正常患儿(P + 6周更容易出现大动作发育迟缓(or值分别为5.504、1.083、1.846)和细动作发育迟缓(or值分别为2.216、1.074、1.011、1.661)。结论:大、精细运动发育迟缓是大多数学龄前ASD儿童可能面临的困难,运动发育迟缓的ASD儿童在社交技能方面存在较大的缺陷。因此,有必要持续监测ASD患儿的大、精细运动发育进展情况,以便于早期识别和个体化干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.

Background: Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool children with ASD, in order to enhance people's awareness of motor developmental delay in ASD children.

Methods: We recruited 1,256 ASD children aged 2-6 years from the China Multi-Center Preschool Autism Project (CMPAP). We investigated the overall status of neurodevelopment in preschool children with ASD through the Revised Children Neuropsychological and Behavior Scale (CNBS-R2016) and the Gesell Developmental Scale (GDS). The multivariate ordered logistic regression model was used to analyze the relationship between different degrees of motor developmental delay and demographic, core symptoms of ASD, and maternal risk factors, which were evaluated using the questionnaires, the Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale-Second Edition (SRS-2).

Results: The proportions of delayed development in various neurodevelopmental domains was significantly imbalanced in preschool children with ASD. The proportions of gross and fine motor developmental delay were as high as 39.6% and 68.4% respectively. ASD children in different age subgroups all exhibited gross and fine motor developmental delay. The CARS and SRS-2 total scores of ASD children with mild, moderate-severe gross or fine motor developmental delay were significantly higher than those with normal motor skills development (P < 0.05). ASD children aged ≥ 5 years, or higher CARS and SRS-2 total scores, or gestational age in the 28-36+ 6 weeks were more likely to suffer from gross motor developmental delay (OR values were 5.504, 1.083, 1.846 respectively) and fine motor developmental delay (OR values were 2.216, 1.074, 1.011, 1.661 respectively).

Conclusion: Gross and fine motor developmental delay were difficulties that most preschool children with ASD may face, and ASD children with motor developmental delay had greater deficits in social skills. Therefore, it is necessary to continuously monitor the gross and fine motor development progress of children with ASD for facilitating early identification and individualized intervention.

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来源期刊
Child and Adolescent Psychiatry and Mental Health
Child and Adolescent Psychiatry and Mental Health PEDIATRICSPSYCHIATRY-PSYCHIATRY
CiteScore
7.00
自引率
3.60%
发文量
84
审稿时长
16 weeks
期刊介绍: Child and Adolescent Psychiatry and Mental Health, the official journal of the International Association for Child and Adolescent Psychiatry and Allied Professions, is an open access, online journal that provides an international platform for rapid and comprehensive scientific communication on child and adolescent mental health across different cultural backgrounds. CAPMH serves as a scientifically rigorous and broadly open forum for both interdisciplinary and cross-cultural exchange of research information, involving psychiatrists, paediatricians, psychologists, neuroscientists, and allied disciplines. The journal focusses on improving the knowledge base for the diagnosis, prognosis and treatment of mental health conditions in children and adolescents, and aims to integrate basic science, clinical research and the practical implementation of research findings. In addition, aspects which are still underrepresented in the traditional journals such as neurobiology and neuropsychology of psychiatric disorders in childhood and adolescence are considered.
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