端粒长度与衰老相关疾病的关系。

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Medicine Pub Date : 2025-03-05 DOI:10.1007/s10238-025-01608-z

Xuanqi Huang, Leyi Huang, Jiaweng Lu, Lijuan Cheng, Du Wu, Linmeng Li, Shuting Zhang, Xinyue Lai, Lu Xu

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引用次数: 0

摘要

随着全球人口老龄化现象的加剧，对老龄化和与老龄化有关的疾病的研究日益受到重视。细胞衰老和衰老是由端粒缩短引起的。端粒长度（TL）作为一种生物标志物受到了严格的审查，并广泛应用于与年龄增长有关的疾病的研究。本文综述了端粒与衰老相关疾病之间的关系，探讨了功能障碍端粒在这些疾病发生和发展中的重要作用，旨在为开发新的治疗策略提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The relationship between telomere length and aging-related diseases.

The intensifying global phenomenon of an aging population has spurred a heightened emphasis on studies on aging and disorders associated with aging. Cellular senescence and aging are known to be caused by telomere shortening. Telomere length (TL) has emerged as a biomarker under intense scrutiny, and its widespread use in investigations of diseases tied to advancing age. This review summarizes the current knowledge of the association between telomeres and aging-related diseases, explores the important contribution of dysfunctional telomeres to the development and progression of these diseases, and aims to provide valuable insights for the development of novel therapeutic strategies.

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来源期刊

Clinical and Experimental Medicine 医学-医学：研究与实验

CiteScore

4.80

自引率

2.20%

发文量

159

审稿时长

2.5 months

期刊介绍： Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.