在瑞士日内瓦分离出广泛耐药流感嗜血杆菌。

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI:10.1007/s10096-025-05093-w

Abdessalam Cherkaoui, Patrice Francois, Nadia Gaia, Gesuele Renzi, Adrien Fischer, Jacques Schrenzel

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引用次数: 0

摘要

在一些亚洲国家观察到流感嗜血杆菌中出现多重耐药（MDR）甚至广泛耐药（XDR）菌株。在此，我们报告了在瑞士日内瓦分离到的首例XDR流感嗜血杆菌。该菌株是从一名63岁男性患者的优质痰样本中分离出来的。当时没有呼吸道感染的诊断。该菌株不可分型，具有pan-β-内酰胺抗性。经全基因组测序分析，属序列型159和ST-107克隆复合体。根据在PBP3转肽酶结构域发现的氨基酸取代，将其归类为III +族。

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Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland.

The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among H. influenzae was observed in some Asian countries. Herein, we reported the first XDR H. influenzae isolated in Geneva, Switzerland. This strain was isolated in a good-quality sputum sample from a 63 year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.