Yuriko Mori, Katharina Tamburini, Emil Novruzov, Dominik Schmitt, Eleni Mavriopoulou, Sven H. Loosen, Christoph Roderburg, Tadashi Watabe, Clemens Kratochwil, Manuel Röhrich, Abass Alavi, Uwe Haberkorn, Frederik L. Giesel
{"title":"[68Ga]Ga-FAPI-PET作为肝纤维化无创评价方法的疗效","authors":"Yuriko Mori, Katharina Tamburini, Emil Novruzov, Dominik Schmitt, Eleni Mavriopoulou, Sven H. Loosen, Christoph Roderburg, Tadashi Watabe, Clemens Kratochwil, Manuel Röhrich, Abass Alavi, Uwe Haberkorn, Frederik L. Giesel","doi":"10.1007/s12149-025-02027-6","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Liver fibrosis is a chronic fibrosing hepatic disorder following recurrent injury, characterized by the excessive accumulation of extracellular matrix. Early detection has a great clinical impact because 80–90% of hepatocellular carcinomas are known to develop in fibrotic or cirrhotic (end-stage fibrotic) livers. PET imaging with FAP ligands exhibited highly promising results in recent years to visualize fibrosis in various organs due to the crucial role of activated fibroblasts in fibrosing processes. However, still little is known about the efficacy of FAP imaging in liver fibrosis. Thus, we sought to investigate the potential of FAPI-PET in a cohort of oncological and non-oncological patients.</p><h3>Methods</h3><p>199 patients who underwent FAPI-PET/CT at the University Hospital of Heidelberg between July 2017 and July 2020 were retrospectively analyzed. The tracer uptake of the liver was analyzed and correlated with radiological and clinical parameters.</p><h3>Results</h3><p>We observed a weak but significant negative correlation between the hepatic FAPI uptake and CT density (<i>r</i> = − 0.273, <i>P</i> < 0.001***). A positive correlation was observed between hepatic FAPI uptake and the aspartate aminotransferase (AST)-to-platelet ratio index (APRI) (<i>r</i> = 0.183, <i>P</i> = 0.009**), an established surrogate for liver fibrosis. The liver SUV (standardized uptake value) mean and SUVmax of FAPI showed significant differences between groups of patients with low (< 0.5), middle (0.5–1.0) and higher (> 1.0) levels of APRI (both <i>P</i> < 0.001***).</p><h3>Conclusion</h3><p>These preliminary observational results suggest that FAPI-PET may be a viable non-invasive method to asses liver fibrosis.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 6","pages":"631 - 639"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-025-02027-6.pdf","citationCount":"0","resultStr":"{\"title\":\"Efficacy of [68Ga]Ga-FAPI-PET as a non-invasive evaluation method of liver fibrosis\",\"authors\":\"Yuriko Mori, Katharina Tamburini, Emil Novruzov, Dominik Schmitt, Eleni Mavriopoulou, Sven H. Loosen, Christoph Roderburg, Tadashi Watabe, Clemens Kratochwil, Manuel Röhrich, Abass Alavi, Uwe Haberkorn, Frederik L. Giesel\",\"doi\":\"10.1007/s12149-025-02027-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Liver fibrosis is a chronic fibrosing hepatic disorder following recurrent injury, characterized by the excessive accumulation of extracellular matrix. Early detection has a great clinical impact because 80–90% of hepatocellular carcinomas are known to develop in fibrotic or cirrhotic (end-stage fibrotic) livers. PET imaging with FAP ligands exhibited highly promising results in recent years to visualize fibrosis in various organs due to the crucial role of activated fibroblasts in fibrosing processes. However, still little is known about the efficacy of FAP imaging in liver fibrosis. Thus, we sought to investigate the potential of FAPI-PET in a cohort of oncological and non-oncological patients.</p><h3>Methods</h3><p>199 patients who underwent FAPI-PET/CT at the University Hospital of Heidelberg between July 2017 and July 2020 were retrospectively analyzed. The tracer uptake of the liver was analyzed and correlated with radiological and clinical parameters.</p><h3>Results</h3><p>We observed a weak but significant negative correlation between the hepatic FAPI uptake and CT density (<i>r</i> = − 0.273, <i>P</i> < 0.001***). A positive correlation was observed between hepatic FAPI uptake and the aspartate aminotransferase (AST)-to-platelet ratio index (APRI) (<i>r</i> = 0.183, <i>P</i> = 0.009**), an established surrogate for liver fibrosis. The liver SUV (standardized uptake value) mean and SUVmax of FAPI showed significant differences between groups of patients with low (< 0.5), middle (0.5–1.0) and higher (> 1.0) levels of APRI (both <i>P</i> < 0.001***).</p><h3>Conclusion</h3><p>These preliminary observational results suggest that FAPI-PET may be a viable non-invasive method to asses liver fibrosis.</p></div>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":\"39 6\",\"pages\":\"631 - 639\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s12149-025-02027-6.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12149-025-02027-6\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-025-02027-6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
肝纤维化是一种复发性损伤后的慢性纤维化肝脏疾病，其特征是细胞外基质的过度积累。早期发现具有重要的临床意义，因为已知80-90%的肝细胞癌发生于纤维化或肝硬化（终末期纤维化）肝脏。近年来，由于活化的成纤维细胞在纤维化过程中的关键作用，FAP配体的PET成像在观察各种器官的纤维化方面显示出非常有希望的结果。然而，关于FAP成像在肝纤维化中的作用，我们所知甚少。因此，我们试图研究FAPI-PET在肿瘤和非肿瘤患者队列中的潜力。方法：回顾性分析2017年7月至2020年7月在海德堡大学医院接受FAPI-PET/CT检查的199例患者。分析肝脏示踪剂摄取情况，并与影像学和临床参数相关联。结果：我们观察到肝脏FAPI摄取与CT密度之间呈微弱但显著的负相关（r = - 0.273, P 1.0）。结论：这些初步观察结果表明，FAPI- pet可能是一种可行的无创肝纤维化评估方法。
Efficacy of [68Ga]Ga-FAPI-PET as a non-invasive evaluation method of liver fibrosis
Introduction
Liver fibrosis is a chronic fibrosing hepatic disorder following recurrent injury, characterized by the excessive accumulation of extracellular matrix. Early detection has a great clinical impact because 80–90% of hepatocellular carcinomas are known to develop in fibrotic or cirrhotic (end-stage fibrotic) livers. PET imaging with FAP ligands exhibited highly promising results in recent years to visualize fibrosis in various organs due to the crucial role of activated fibroblasts in fibrosing processes. However, still little is known about the efficacy of FAP imaging in liver fibrosis. Thus, we sought to investigate the potential of FAPI-PET in a cohort of oncological and non-oncological patients.
Methods
199 patients who underwent FAPI-PET/CT at the University Hospital of Heidelberg between July 2017 and July 2020 were retrospectively analyzed. The tracer uptake of the liver was analyzed and correlated with radiological and clinical parameters.
Results
We observed a weak but significant negative correlation between the hepatic FAPI uptake and CT density (r = − 0.273, P < 0.001***). A positive correlation was observed between hepatic FAPI uptake and the aspartate aminotransferase (AST)-to-platelet ratio index (APRI) (r = 0.183, P = 0.009**), an established surrogate for liver fibrosis. The liver SUV (standardized uptake value) mean and SUVmax of FAPI showed significant differences between groups of patients with low (< 0.5), middle (0.5–1.0) and higher (> 1.0) levels of APRI (both P < 0.001***).
Conclusion
These preliminary observational results suggest that FAPI-PET may be a viable non-invasive method to asses liver fibrosis.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
