通过接枝两性离子水凝胶膜在腔内表面增强粘液流动和清除

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Laryngoscope Investigative Otolaryngology Pub Date : 2025-03-07 DOI:10.1002/lio2.70118

Ryan Horne, Caleb Escudero, Morgan Ellerman, C. Allan Guymon, Marlan Hansen

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引用次数: 0

摘要

目的探讨两性离子水凝胶膜对医用高分子材料平面和管状表面黏液接触角、流动和停滞的影响。方法将两性离子水凝胶薄膜光接于医用橡胶表面，并与非两性离子水凝胶薄膜和未经处理的表面进行比较，考察其对黏液接触角、黏液在片管上流动和黏液堵塞的影响。结果两性离子水凝胶膜和常规水凝胶膜显著降低了粘液接触角和倾斜程度，从而使粘液在片状和管状系统中流动。初步实验表明，这些膜也可以缩短粘管在接触生理盐水时拔出粘管所需的时间。结论典型医用表面的两性离子水凝胶膜和常规水凝胶膜降低了黏液流动阻力，增加了黏液排出量，有利于干燥黏液的快速拔出。这些效应在内径较大（大于2.6 mm）的管子上最为明显，而对于内径较小的管子则趋于消散。这些结果可能有助于指导未来用于排出粘液和通气的医用管的改进，从而减少患者的并发症。证据水平2级，随机个体试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces

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Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces

Objective

To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.

Methods

A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non-zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging.

Results

Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten the time required for a mucus-plugged tube to unplug when exposed to saline.

Conclusion

Zwitterionic and conventional hydrogel films on typical medical surfaces reduce resistance to mucus flow, increase mucus discharge, and may facilitate faster unplugging of dried mucus. These effects are the most pronounced on tubes of larger inner diameter (greater than 2.6 mm) and tend to dissipate for tubes of smaller diameter. These results may help guide future improvements to medical tubes intended to discharge mucus and ventilate, resulting in fewer complications for patients.