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IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2025-03-07 DOI:10.1002/cre2.70108

Najla S. Alrejaye, Mostafa A. Abolfotouh, Fathima Fazrina Farook, Elaf Mubarak Abdullah Algharbi, Abdulmajeed Mohammed B. Alharbi, Halah Ibrahim Alshuaibi, Mai Saad Bin Akresh, AlAnood Naif Bin Saedan, Nouf Besher Albesher, Atheer Sami Aldaham, Lujain Ahmad Alghrairy, Latifa Yousef AlGudaibi, Rana Abdullah Alolaiq, Afnan Turki Alzomaili, Mosleh S. Alharbi

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引用次数: 0

摘要

目的本研究旨在确定与沙特儿童非综合征性口面裂（NSOFCs）相关的风险因素。材料和方法国民卫队卫生事务部开展了一项病例对照研究。病例为患有 NSOFCs 的儿童，他们与同一环境中的健康对照组在性别和出生年份上进行了配对。有关风险因素的数据是通过使用有效问卷对病例和对照组的父母进行访谈收集的。问卷内容包括父亲和母亲的信息以及孩子的信息。显著性水平定为 0.05。采用比值比（OR）和95%置信区间（CI）来确定非颅内压增高症的相关风险因素。结果共纳入 188 名儿童（88 例病例和 100 例对照），平均年龄为 5.1 ± 2.3 岁。母亲在怀孕期间发烧与罹患 NSOFCs 的风险显著相关（OR = 3.4，95% CI：0.05-2.5，p < 0.05）。此外，患有口面裂的母系亲属也会增加风险（OR = 6.02，95% CI：0.43-3.16，p < 0.001），而最强的预测因素是患有口面裂的父系亲属（OR = 8.00，95% CI：0.41-3.75，p = 0.014）。这些发现对于了解和潜在预防非颌面部裂极为重要。结论父系或母系亲属中有人患有口面裂以及孕妇在怀孕头三个月发烧都是非颌面裂婴儿的预测因素，其中父系亲属中有人患有口面裂是最强的预测因素。

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Risk Factors for Nonsyndromic Orofacial Clefts Among Saudi Children

Objectives

The aim of this study was to identify the risk factors associated with nonsyndromic orofacial clefts (NSOFCs) among Saudi children.

Materials and Methods

A case–control study was carried out at the Ministry of National Guard Health Affairs. Cases were children with NSOFCs who were matched by gender and year of birth to healthy controls from the same setting. Data on risk factors were collected by interviewing parents of both cases and controls using a validated questionnaire. The questionnaire consisted of the father's and mother's information and the child's information. The level of significance was set at 0.05. Odds ratio (OR) and 95% confidence intervals (CIs) were used to determine the associated risk factors with NSOFCs.

Results

A total of 188 children were included (88 cases and 100 controls), with a mean age of 5.1 ± 2.3 years. Maternal fever during pregnancy was associated with a significantly higher risk of NSOFCs (OR = 3.4, 95% CI: 0.05–2.5, p < 0.05). Additionally, the presence of maternal relatives with orofacial clefts increased the risk (OR = 6.02, 95% CI: 0.43–3.16, p < 0.001), whereas the strongest predictor was paternal relatives with orofacial clefts (OR = 8.00, 95% CI: 0.41–3.75, p = 0.014). These findings are of utmost importance for the understanding and potential prevention of NSOFCs.

Conclusions

The presence of paternal or maternal relatives with orofacial clefts and maternal fever during the first trimester were predictors for NSOFCs, with having affected paternal relatives being the strongest predictor.

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.