硝酸锂对失活芳香族化合物的硝化作用

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-03-03 DOI:10.1016/j.tetlet.2025.155515

Weihao Ma , J. Tyler McBride , Robert S. Phillips

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引用次数: 0

摘要

硝基芳烃在药物化学、材料科学和化学工业中至关重要。本文介绍了一种利用硝酸锂（LiNO3）在三氟乙酸中硫酸存在下对失活芳香族化合物进行亲电硝化的新策略。该方法的产率为中等至优异。温和的反应条件和易于加工使得硝基化合物的合成既实用又具有商业可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nitration of deactivated aromatic compounds using Lithium nitrate

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Nitration of deactivated aromatic compounds using Lithium nitrate

Nitroarenes are critically important in medicinal chemistry, material science, and the chemical industry. In this paper, we introduce a new strategy for the electrophilic nitration of deactivated aromatic compounds, utilizing lithium nitrate (LiNO₃) in the presence of sulfuric acid in trifluoroacetic acid. This method has demonstrated moderate to excellent yield. Mild reaction conditions and easy workup make the synthesis of nitro compounds both practical and commercially feasible.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.